Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii(toxin)
Location 2143909..2144980 Replicon chromosome
Accession NZ_CP013050
Organism Thermococcus barophilus strain CH5

Toxin (Protein)


Gene name PygT Uniprot ID -
Locus tag TBCH5v1_RS13730 Protein ID WP_056934755.1
Coordinates 2143909..2144367 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name PygA Uniprot ID -
Locus tag TBCH5v1_RS11895 Protein ID WP_056934756.1
Coordinates 2144351..2144980 (-) Length 210 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBCH5v1_RS11855 (TBCH5v1_2458) 2139388..2140791 + 1404 WP_056934750.1 alkaline phosphatase family protein -
TBCH5v1_RS11860 (TBCH5v1_2459) 2140845..2141060 + 216 WP_013468331.1 DUF2283 domain-containing protein -
TBCH5v1_RS11865 (TBCH5v1_2460) 2141070..2141594 + 525 WP_200956736.1 adenylyl-sulfate kinase -
TBCH5v1_RS11870 (TBCH5v1_2461) 2141605..2142345 + 741 WP_056934752.1 sulfite exporter TauE/SafE family protein -
TBCH5v1_RS11875 (TBCH5v1_2462) 2142501..2142761 + 261 WP_056934753.1 UPF0175 family protein -
TBCH5v1_RS13705 (TBCH5v1_2463) 2142758..2143003 + 246 WP_235507118.1 hypothetical protein -
TBCH5v1_RS13710 (TBCH5v1_2464) 2142990..2143247 + 258 WP_235507119.1 DUF3368 domain-containing protein -
TBCH5v1_RS13725 (TBCH5v1_2466) 2143440..2143850 - 411 WP_158508417.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
TBCH5v1_RS13730 (TBCH5v1_2467) 2143909..2144367 - 459 WP_056934755.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
TBCH5v1_RS11895 (TBCH5v1_2468) 2144351..2144980 - 630 WP_056934756.1 hypothetical protein Antitoxin
TBCH5v1_RS11900 (TBCH5v1_2469) 2145258..2146190 - 933 WP_056934757.1 hypothetical protein -
TBCH5v1_RS11905 (TBCH5v1_2470) 2146353..2147249 - 897 WP_056934758.1 DUF234 domain-containing protein -
TBCH5v1_RS11910 (TBCH5v1_2471) 2147644..2147874 + 231 WP_013468345.1 hypothetical protein -
TBCH5v1_RS11915 (TBCH5v1_2472) 2147861..2148277 + 417 WP_056934759.1 type II toxin-antitoxin system VapC family toxin -
TBCH5v1_RS11920 (TBCH5v1_2473) 2148535..2148804 + 270 WP_056934760.1 hypothetical protein -
TBCH5v1_RS11925 (TBCH5v1_2474) 2148779..2149138 + 360 WP_056934761.1 DUF6516 family protein -
TBCH5v1_RS11930 (TBCH5v1_2475) 2149363..2149953 + 591 WP_056934762.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-152)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 18133.01 Da        Isoelectric Point: 9.3753

>T57845 WP_056934755.1 NZ_CP013050:c2144367-2143909 [Thermococcus barophilus]
MKDYSEFIQLIIEKSRIKKPELVEKDIILHTILKKLYSNEYFAQNYLFKGETCLVKCYFDYYRFSVDLDFTLKNQEKWNG
LSKRSRRKVLVEEAQRIGDLIEAAANHISLEFKAELRDKRYIEFGSGSRMVTYKLYYPCREGNLIKVQVNFG

Download         Length: 459 bp

>T57845 NZ_CP013050:c2144367-2143909 [Thermococcus barophilus]
ATGAAGGACTACTCTGAGTTTATCCAATTAATAATTGAGAAGAGCAGGATTAAGAAGCCAGAACTAGTTGAGAAGGATAT
AATCCTGCACACAATTTTAAAGAAACTCTACTCCAACGAGTATTTTGCCCAAAACTACCTTTTTAAAGGTGAAACTTGCT
TAGTCAAATGTTATTTCGACTATTATCGTTTCAGCGTTGATCTTGACTTTACTCTTAAGAATCAGGAGAAGTGGAATGGA
CTCTCAAAAAGAAGCAGGAGAAAAGTCCTCGTCGAAGAAGCGCAAAGGATTGGCGATCTAATTGAGGCTGCTGCCAACCA
CATTAGTCTTGAATTTAAGGCTGAACTGCGGGATAAACGCTACATCGAGTTTGGGAGTGGTTCAAGAATGGTAACGTACA
AGTTGTATTATCCCTGTAGGGAAGGCAACTTGATAAAGGTTCAGGTTAATTTTGGTTGA

Antitoxin


Download         Length: 210 a.a.        Molecular weight: 24683.14 Da        Isoelectric Point: 10.0189

>AT57845 WP_056934756.1 NZ_CP013050:c2144980-2144351 [Thermococcus barophilus]
MNIAVKFLLSRYGGKVITKGELKKVCERFGVDVDYLIHHLISYGYVIRILRGVYYVKTVEEFKLKKALRPLEIIGLGLNK
LGVKWYYGLFTALRLNALTHEYFTRIFVLNDRIYRSKIVKIYGEDVEFIKIKPHLTEFGIIDKGEIKYSDVEKTLLDFLY
LSRYNPKLRFTAKNTVAEYWDKANKEKINEYLKYYPKSLKKVLENEGLL

Download         Length: 630 bp

>AT57845 NZ_CP013050:c2144980-2144351 [Thermococcus barophilus]
ATGAACATCGCAGTAAAGTTCCTCCTATCTAGATATGGCGGGAAAGTCATTACAAAAGGAGAGCTAAAAAAAGTATGTGA
GAGATTTGGAGTTGATGTTGACTATTTGATACACCACCTTATATCTTATGGGTACGTAATTAGAATTCTTCGCGGTGTTT
ATTACGTGAAGACTGTTGAGGAGTTTAAGCTGAAAAAGGCTTTAAGACCATTAGAAATCATTGGGCTCGGATTGAACAAG
CTGGGCGTAAAATGGTACTACGGCCTGTTTACAGCCCTCAGATTAAATGCTCTCACCCACGAATACTTCACAAGAATATT
CGTTCTAAACGATAGAATTTACCGCTCAAAGATTGTGAAGATTTATGGAGAAGATGTTGAATTTATAAAAATCAAACCTC
ACCTGACAGAGTTCGGCATCATAGATAAAGGAGAGATAAAATATTCTGACGTAGAAAAAACCCTCTTAGATTTCCTCTAT
CTTTCAAGGTACAATCCAAAACTCAGGTTCACTGCAAAAAATACTGTGGCAGAGTATTGGGACAAGGCGAATAAAGAAAA
AATAAATGAATACCTCAAGTACTATCCCAAATCTCTAAAAAAGGTGCTTGAGAATGAAGGACTACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References