Detailed information of TA system TA057844

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii(toxin)
• Location: 2066983..2067874
• Replicon: chromosome
• Accession: NZ_CP013050
• Organism: Thermococcus barophilus strain CH5

Toxin (Protein)

• Gene name: PygT
• Uniprot ID: -
• Locus tag: TBCH5v1_RS11450
• Protein ID: WP_056934695.1
• Coordinates: 2066983..2067255 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: PygA
• Uniprot ID: -
• Locus tag: TBCH5v1_RS11455
• Protein ID: WP_235507115.1
• Coordinates: 2067248..2067874 (-)
• Length: 209 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBCH5v1_RS11435 (TBCH5v1_2377)	2063899..2065407	-	1509	WP_056934692.1	hypothetical protein	-
TBCH5v1_RS11440 (TBCH5v1_2378)	2065631..2065930	+	300	WP_056934693.1	hypothetical protein	-
TBCH5v1_RS11445 (TBCH5v1_2379)	2065963..2066355	-	393	WP_056934694.1	hypothetical protein	-
TBCH5v1_RS13430 (TBCH5v1_2380)	2066441..2066578	-	138	WP_158508415.1	hypothetical protein	-
TBCH5v1_RS11450 (TBCH5v1_2381)	2066983..2067255	-	273	WP_056934695.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
TBCH5v1_RS11455 (TBCH5v1_2382)	2067248..2067874	-	627	WP_235507115.1	hypothetical protein	Antitoxin
TBCH5v1_RS11465 (TBCH5v1_2383)	2068305..2068562	+	258	WP_056934696.1	hypothetical protein	-
TBCH5v1_RS11485 (TBCH5v1_2384)	2069154..2069729	+	576	WP_056934697.1	SMC-Scp complex subunit ScpB	-
TBCH5v1_RS11490 (TBCH5v1_2385)	2069853..2070920	+	1068	WP_056934698.1	OB-fold nucleic acid binding domain-containing protein	-
TBCH5v1_RS11495 (TBCH5v1_2386)	2070920..2071282	+	363	WP_013468267.1	hypothetical protein	-
TBCH5v1_RS11500 (TBCH5v1_2387)	2071279..2072082	+	804	WP_056934699.1	OB-fold nucleic acid binding domain-containing protein	-
TBCH5v1_RS11505 (TBCH5v1_2388)	2072127..2072504	-	378	WP_193385919.1	ribonucleoside-triphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (30-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10584.42 Da
• Isoelectric Point: 9.7213

>T57844 WP_056934695.1 NZ_CP013050:c2067255-2066983 [Thermococcus barophilus]
MNREFASFISKKTGIKSLELVERDILLHAILKRLYSDEHFIANYLFKGGTCLVKCYLGYYRFSIDLDFTFSRVEKLSRAN
MNKINKISCF

Nucleotide

• Length: 273 bp

>T57844 NZ_CP013050:c2067255-2066983 [Thermococcus barophilus]
ATGAATAGGGAATTTGCATCATTTATCTCAAAAAAGACTGGAATCAAAAGCCTCGAACTAGTGGAGAGAGACATACTACT
GCATGCAATTTTAAAGAGGCTTTACTCTGATGAACATTTCATTGCGAACTACCTCTTCAAAGGTGGAACTTGCCTTGTCA
AGTGTTATCTCGGATACTACCGCTTTAGTATTGATTTAGACTTCACGTTCTCCAGAGTGGAAAAGCTCTCAAGAGCAAAC
ATGAATAAAATTAATAAAATTTCATGTTTTTGA

Antitoxin

Protein

• Length: 209 a.a.
• Molecular weight: 24742.34 Da
• Isoelectric Point: 10.3774

>AT57844 WP_235507115.1 NZ_CP013050:c2067874-2067248 [Thermococcus barophilus]
MKLMNKYLLKKFGGKIVQKRDLKSLSQKFYIKDFNKWLNYLQYRGYIIRIFRGVYYVKTLEEFLSDSQPSVYELIAMAME
MKTPQWYFGLFTALRLNGVTYEYFTKIFVISDSVKRTKPITIAGESVEFIKIKPPLARFGIRQNGIVKYSNLEKTLLDFL
YLSSYRSISRELALKVFKEYLPKADLRILKRYAKQYPKSILKLVEAYE

Nucleotide

• Length: 627 bp

>AT57844 NZ_CP013050:c2067874-2067248 [Thermococcus barophilus]
ATGAAACTTATGAACAAATACCTACTAAAAAAATTTGGAGGGAAAATAGTTCAAAAACGTGATTTAAAATCACTCAGTCA
AAAATTTTACATAAAAGACTTTAATAAGTGGCTTAATTACCTCCAGTATCGAGGCTACATCATTAGAATTTTTCGTGGCG
TTTATTATGTTAAAACACTCGAAGAATTTCTCTCAGATTCTCAGCCGAGTGTCTATGAGTTGATTGCAATGGCCATGGAA
ATGAAAACTCCCCAGTGGTACTTCGGCTTGTTCACTGCCCTCCGCCTGAATGGCGTTACGTATGAATACTTCACCAAAAT
TTTCGTAATAAGTGATAGCGTGAAAAGGACCAAGCCAATTACTATCGCTGGAGAGAGCGTTGAGTTCATAAAGATTAAAC
CCCCTCTTGCAAGATTTGGCATAAGACAGAACGGCATTGTAAAGTACTCTAATCTGGAAAAAACTTTGCTGGACTTTCTC
TATCTATCAAGCTATCGCTCCATTTCAAGAGAGCTTGCTTTAAAAGTATTTAAGGAATATTTACCAAAAGCTGACCTGAG
AATACTTAAAAGATATGCCAAACAGTATCCAAAATCAATCTTAAAACTGGTGGAGGCTTATGAATAG