Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1663931..1664531 Replicon chromosome
Accession NZ_CP013050
Organism Thermococcus barophilus strain CH5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TBCH5v1_RS09375 Protein ID WP_056934361.1
Coordinates 1663931..1664320 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TBCH5v1_RS09380 Protein ID WP_056934362.1
Coordinates 1664307..1664531 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBCH5v1_RS09350 (TBCH5v1_1939) 1659572..1660174 + 603 WP_056934357.1 DUF998 domain-containing protein -
TBCH5v1_RS09355 (TBCH5v1_1940) 1660158..1661621 - 1464 WP_056934358.1 S-layer protein -
TBCH5v1_RS09360 (TBCH5v1_1942) 1661744..1662220 + 477 WP_048159806.1 DUF2391 family protein -
TBCH5v1_RS09365 (TBCH5v1_1943) 1662221..1663225 + 1005 WP_056934359.1 DUF3226 domain-containing protein -
TBCH5v1_RS09370 (TBCH5v1_1944) 1663222..1663914 + 693 WP_056934360.1 HAD family hydrolase -
TBCH5v1_RS09375 (TBCH5v1_1945) 1663931..1664320 - 390 WP_056934361.1 type II toxin-antitoxin system VapC family toxin Toxin
TBCH5v1_RS09380 (TBCH5v1_1946) 1664307..1664531 - 225 WP_056934362.1 hypothetical protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Putative antitoxin VapB3-like

(1-74)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14544.96 Da        Isoelectric Point: 4.9539

>T57843 WP_056934361.1 NZ_CP013050:c1664320-1663931 [Thermococcus barophilus]
VIVIDASLLVKVILKEEGWENVPIDTSTATLDYAFVEGMNAIWVAVRRKRIDESEARSRVLVLKLLGESMTLFSAGNFFE
RGLEIALKENITIYDALYIALAEALNVELYTADNKQYMAAKKYVRAKLI

Download         Length: 390 bp

>T57843 NZ_CP013050:c1664320-1663931 [Thermococcus barophilus]
GTGATAGTCATTGATGCATCCTTGCTGGTCAAAGTCATCCTCAAAGAGGAAGGTTGGGAAAATGTTCCGATTGACACCAG
CACAGCTACACTGGACTATGCGTTCGTTGAAGGTATGAATGCAATATGGGTTGCAGTTAGGAGAAAGAGGATAGATGAAA
GCGAAGCCCGCTCCAGAGTTCTTGTGCTCAAACTTTTAGGGGAGAGTATGACTCTATTCAGTGCAGGAAACTTCTTTGAA
AGGGGATTAGAGATAGCACTGAAGGAAAACATAACAATTTACGATGCCCTTTATATAGCCTTAGCCGAAGCTTTGAACGT
TGAGCTTTATACGGCCGATAACAAGCAATATATGGCTGCCAAAAAATATGTGAGGGCAAAACTGATTTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8964.44 Da        Isoelectric Point: 10.8578

>AT57843 WP_056934362.1 NZ_CP013050:c1664531-1664307 [Thermococcus barophilus]
MAIITVRVPDELKLKMKQLNINWSEEIREFIRRRIDEEERRRKLKKALEILRQSRGSVEMGFSAKVVREDRDSH

Download         Length: 225 bp

>AT57843 NZ_CP013050:c1664531-1664307 [Thermococcus barophilus]
ATGGCGATAATTACAGTTCGAGTTCCCGATGAGTTAAAGCTGAAAATGAAACAGCTCAACATTAACTGGAGTGAAGAGAT
AAGAGAGTTCATCAGACGACGGATAGATGAAGAAGAAAGAAGGAGAAAACTAAAAAAGGCTCTTGAAATTCTCAGACAAA
GCAGAGGTTCAGTTGAGATGGGTTTCTCAGCAAAGGTAGTGAGGGAGGATCGTGATAGTCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References