Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 38618..39261 Replicon plasmid unnamed1
Accession NZ_CP013047
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name vagD Uniprot ID A0A0P0QKL4
Locus tag AR325_RS26350 Protein ID WP_060560552.1
Coordinates 38618..39034 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0N7JQI1
Locus tag AR325_RS26355 Protein ID WP_060560551.1
Coordinates 39031..39261 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS26325 34263..35066 - 804 WP_060560555.1 winged helix-turn-helix domain-containing protein -
AR325_RS26330 36020..36889 - 870 WP_060560554.1 WYL domain-containing protein -
AR325_RS27345 36999..37169 + 171 WP_194286134.1 hypothetical protein -
AR325_RS26345 37904..38305 + 402 WP_060560553.1 hypothetical protein -
AR325_RS26350 38618..39034 - 417 WP_060560552.1 type II toxin-antitoxin system VapC family toxin Toxin
AR325_RS26355 39031..39261 - 231 WP_060560551.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AR325_RS26360 39693..40070 + 378 WP_060560550.1 Ltp family lipoprotein -
AR325_RS26365 40324..42582 - 2259 WP_079007675.1 NTPase -
AR325_RS26370 42585..43616 - 1032 WP_153303171.1 hypothetical protein -
AR325_RS26375 43837..44019 + 183 WP_060560548.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..123171 123171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15032.32 Da        Isoelectric Point: 7.2448

>T57841 WP_060560552.1 NZ_CP013047:c39034-38618 [Serratia marcescens]
VNKTYMLDTNICSFIMREQPEAVIKRLEQAVLRNHRIVVSAITYAEMRFGAVGKKASPRHTQLVDAFCARLDAILSWDRA
AVDATTEIKAALAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVADLVLEDWVK

Download         Length: 417 bp

>T57841 NZ_CP013047:c39034-38618 [Serratia marcescens]
GTGAACAAGACCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAACAGCCGGAAGCCGTCATTAAACGCTT
GGAGCAGGCGGTGCTGCGTAACCACCGCATCGTGGTTTCGGCCATCACTTATGCCGAAATGCGTTTCGGCGCTGTCGGCA
AGAAGGCCTCGCCGCGCCACACGCAGCTGGTTGACGCCTTCTGCGCTCGCCTTGATGCCATCCTGTCCTGGGATCGTGCC
GCGGTGGACGCCACTACCGAGATCAAGGCTGCCCTGGCCGCAGCCGGGACACCGATCGGCCCGAACGACACGGCGATCGC
CGGCCACGCGATTGCCGCCGGCGCCATACTGGTGACGAATAATACGCGAGAATTTGAGCGGGTAGCGGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8673.79 Da        Isoelectric Point: 4.5742

>AT57841 WP_060560551.1 NZ_CP013047:c39261-39031 [Serratia marcescens]
MRTVSIFKNGNNRAIRLPRDLDFQGVSELEIVREGDNIILRPVRPTWGSFTQLEKADPDFMAERADVVSDEGRVDL

Download         Length: 231 bp

>AT57841 NZ_CP013047:c39261-39031 [Serratia marcescens]
ATGCGAACCGTATCGATATTTAAAAACGGCAACAACCGTGCCATCCGCCTGCCCCGCGATCTGGATTTTCAGGGGGTGAG
TGAGCTCGAGATCGTTCGGGAAGGGGACAATATCATCCTGCGTCCCGTCCGCCCGACCTGGGGGTCGTTCACGCAGCTGG
AAAAGGCCGATCCTGACTTTATGGCGGAGCGTGCGGATGTAGTCAGCGACGAAGGACGAGTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QKL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0N7JQI1

References