Detailed information of TA system TA057837

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4454653..4455322
• Replicon: chromosome
• Accession: NZ_CP013046
• Organism: Serratia marcescens strain B3R3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A0P0QIF8
• Locus tag: AR325_RS21475
• Protein ID: WP_033632171.1
• Coordinates: 4454653..4455075 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: AR325_RS21480
• Protein ID: WP_004931679.1
• Coordinates: 4455056..4455322 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AR325_RS21455	4450545..4451063	+	519	WP_004931683.1	flavodoxin FldB	-
AR325_RS21460	4451098..4452462	-	1365	WP_060560181.1	cell envelope integrity protein CreD	-
AR325_RS21465	4452543..4453961	-	1419	WP_033632173.1	two-component system sensor histidine kinase CreC	-
AR325_RS21470	4453958..4454653	-	696	WP_033632172.1	two-component system response regulator CreB	-
AR325_RS21475	4454653..4455075	-	423	WP_033632171.1	protein YgfX	Toxin
AR325_RS21480	4455056..4455322	-	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
AR325_RS21485	4455644..4456636	+	993	WP_033632169.1	tRNA-modifying protein YgfZ	-
AR325_RS21490	4456675..4457172	-	498	WP_004931675.1	DUF2165 domain-containing protein	-
AR325_RS21495	4457323..4457997	-	675	WP_033632168.1	hemolysin III family protein	-
AR325_RS21500	4458181..4458789	+	609	WP_033632167.1	HD domain-containing protein	-
AR325_RS21505	4458830..4459756	-	927	WP_015378971.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4447827..4517369	69542

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16518.60 Da
• Isoelectric Point: 10.8114

>T57837 WP_033632171.1 NZ_CP013046:c4455075-4454653 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEES

Nucleotide

• Length: 423 bp

>T57837 NZ_CP013046:c4455075-4454653 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTAACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGATCGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGACTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAATGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGAATCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT57837 WP_004931679.1 NZ_CP013046:c4455322-4455056 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT57837 NZ_CP013046:c4455322-4455056 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATTTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A0P0QIF8