Detailed information of TA system TA057833

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3560184..3560779
• Replicon: chromosome
• Accession: NZ_CP013046
• Organism: Serratia marcescens strain B3R3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: AR325_RS17185
• Protein ID: WP_071605322.1
• Coordinates: 3560525..3560779 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AR325_RS17180
• Protein ID: WP_031300694.1
• Coordinates: 3560184..3560525 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AR325_RS17160	3555274..3558363	+	3090	WP_060559879.1	beta-galactosidase	-
AR325_RS17170	3558720..3558894	+	175	Protein_3364	portal protein	-
AR325_RS17175	3558928..3560139	-	1212	WP_079007630.1	FRG domain-containing protein	-
AR325_RS17180	3560184..3560525	-	342	WP_031300694.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AR325_RS17185	3560525..3560779	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
AR325_RS17195	3561461..3563167	+	1707	WP_033632620.1	hypothetical protein	-
AR325_RS17200	3563218..3563790	-	573	WP_060559880.1	hypothetical protein	-
AR325_RS17205	3563919..3564809	+	891	WP_033632618.1	LysR family transcriptional regulator	-
AR325_RS17210	3564763..3565500	-	738	WP_139806250.1	autoinducer binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T57833 WP_071605322.1 NZ_CP013046:c3560779-3560525 [Serratia marcescens]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T57833 NZ_CP013046:c3560779-3560525 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCCCTTTTTACCGCATTAGGGGCGGAGATTCATGAAAGGGAAGGTTCTAGGATCGCGGTGTTGTTGAAAGGTGAAAAAA
GAGTCTTTCATCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGTTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12332.86 Da
• Isoelectric Point: 4.5562

>AT57833 WP_031300694.1 NZ_CP013046:c3560525-3560184 [Serratia marcescens]
MNNTLKIGGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGALSLAVFLDECQKDGIEPYKSYSGKVTTRLSP
ERHQALALAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT57833 NZ_CP013046:c3560525-3560184 [Serratia marcescens]
ATGAACAACACACTGAAAATTGGCGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGTGAGTT
TGTCGGGCTGAACGGTGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGCTCTCACTCGCGG
TCTTTCTGGATGAGTGCCAAAAAGACGGCATCGAGCCTTACAAGTCGTATAGCGGCAAAGTAACCACCCGTTTGTCGCCG
GAACGCCATCAGGCGCTAGCCCTTGCCGCACAGGCGACCGGGCAGTCTATTAATGAGCTGCTGAATGAGGGTGTTGATTT
AGTTATTGAAAAACATTCCTGA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1