Detailed information of TA system TA057832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3300596..3301227
• Replicon: chromosome
• Accession: NZ_CP013046
• Organism: Serratia marcescens strain B3R3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AR325_RS16020
• Protein ID: WP_019452963.1
• Coordinates: 3300596..3300994 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A086GDB9
• Locus tag: AR325_RS16025
• Protein ID: WP_004934853.1
• Coordinates: 3300994..3301227 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AR325_RS15995	3296167..3296538	+	372	WP_048324006.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AR325_RS16000	3296535..3296837	+	303	WP_033632742.1	DNA-binding transcriptional regulator	-
AR325_RS16005	3296840..3297244	-	405	WP_060559818.1	flagellar protein FlhE	-
AR325_RS16010	3297244..3299322	-	2079	WP_033632740.1	flagellar biosynthesis protein FlhA	-
AR325_RS16015	3299315..3300466	-	1152	WP_021504091.1	flagellar type III secretion system protein FlhB	-
AR325_RS16020	3300596..3300994	-	399	WP_019452963.1	type II toxin-antitoxin system VapC family toxin	Toxin
AR325_RS16025	3300994..3301227	-	234	WP_004934853.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AR325_RS16030	3301353..3301997	-	645	WP_004934858.1	protein phosphatase CheZ	-
AR325_RS16035	3302008..3302397	-	390	WP_004934862.1	chemotaxis response regulator CheY	-
AR325_RS16040	3302500..3303549	-	1050	WP_049277000.1	chemotaxis response regulator protein-glutamate methylesterase	-
AR325_RS16045	3303549..3304421	-	873	WP_025159837.1	protein-glutamate O-methyltransferase CheR	-
AR325_RS16050	3304450..3306075	-	1626	WP_004934871.1	Tar ligand binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14876.02 Da
• Isoelectric Point: 8.4955

>T57832 WP_019452963.1 NZ_CP013046:c3300994-3300596 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSVTYGELVHGVEKSSRPAVNARVVEDFVSRLDILDYGAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVDGLRLENWL

Nucleotide

• Length: 399 bp

>T57832 NZ_CP013046:c3300994-3300596 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCGTTCAA
TCGCTATGCGGGCAAAATGGTCATTTCGTCGGTCACCTATGGCGAATTGGTTCACGGAGTGGAGAAAAGCTCGCGTCCGG
CGGTTAATGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACGGCGCCAAAGCGGCTTCGCACTAC
GGCAACATTCGGGCTGCGCTGGAACGTCAGGGAACGCCTATTGGCGTAAACGATCTGCATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATTCTGGTGACCAATAACCGACGCGAATTTGAGCGCGTTGATGGCTTACGGCTGGAAAATTGGCTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8837.86 Da
• Isoelectric Point: 4.7954

>AT57832 WP_004934853.1 NZ_CP013046:c3301227-3300994 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPVENTWDSFFCAENEVSDDFLNERAGQHQREREEL

Nucleotide

• Length: 234 bp

>AT57832 NZ_CP013046:c3301227-3300994 [Serratia marcescens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACGCAGGCCGTGCGCTTGCCTGCAGAGGTGCGTTTCCCCGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCGCCGGTGGAGAATACCTGGGACAGTTTCTTCTGCG
CGGAAAATGAGGTGAGCGATGACTTCCTCAATGAACGTGCCGGGCAACACCAGCGCGAGCGGGAAGAACTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A086GDB9