Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3258694..3259322 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0P0QK57
Locus tag AR325_RS15770 Protein ID WP_015378230.1
Coordinates 3258694..3258897 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A086GDG8
Locus tag AR325_RS15775 Protein ID WP_015378231.1
Coordinates 3258909..3259322 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS15765 3254559..3258530 + 3972 WP_060559807.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
AR325_RS15770 3258694..3258897 + 204 WP_015378230.1 type II toxin-antitoxin system HicA family toxin Toxin
AR325_RS15775 3258909..3259322 + 414 WP_015378231.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AR325_RS15780 3259352..3260104 - 753 WP_033632770.1 L-cystine ABC transporter ATP-binding protein YecC -
AR325_RS15785 3260108..3260770 - 663 WP_015378233.1 cystine ABC transporter permease -
AR325_RS15790 3260770..3261570 - 801 WP_015378234.1 cystine ABC transporter substrate-binding protein -
AR325_RS15795 3261686..3262678 - 993 WP_060559808.1 D-cysteine desulfhydrase -
AR325_RS15800 3262803..3263312 - 510 WP_004934751.1 flagella biosynthesis regulatory protein FliZ -
AR325_RS15805 3263367..3264089 - 723 WP_004934752.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliZ / fliA / fliS 3247442..3267452 20010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7523.89 Da        Isoelectric Point: 11.1475

>T57831 WP_015378230.1 NZ_CP013046:3258694-3258897 [Serratia marcescens]
VKSSELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPHPKKDLKLGTLRQILKDAGLSALHIATR

Download         Length: 204 bp

>T57831 NZ_CP013046:3258694-3258897 [Serratia marcescens]
GTGAAGAGTTCAGAACTGATTGCGCTGCTGGAAAGCCACGGTTGGGTATTGCGGCGGGTAAAAGGCAGCCACCATCAATT
CAAACATCCCGATTTTGCGCTGATCATCACCGTGCCGCATCCAAAGAAAGATCTCAAGCTGGGCACGCTGCGGCAGATAC
TTAAAGACGCGGGGTTAAGTGCGCTTCACATCGCCACGCGTTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14888.63 Da        Isoelectric Point: 5.4867

>AT57831 WP_015378231.1 NZ_CP013046:3258909-3259322 [Serratia marcescens]
MFYPAYIHTESNGSASGFFPDVPGCYFAGTSLDDAFADAQSALDAHFELLSEDNQPLPRPHAVAAHLAKDAGSFEGGQWL
LVAINMDKFDGRAERINITLPHRLLSRIDSLVRQHPGYGSRSGFLAAAARNELLKAE

Download         Length: 414 bp

>AT57831 NZ_CP013046:3258909-3259322 [Serratia marcescens]
ATGTTTTATCCCGCTTATATCCATACAGAATCAAACGGCAGCGCCAGCGGTTTCTTTCCCGACGTCCCTGGCTGCTACTT
CGCCGGCACCAGCCTGGACGACGCTTTTGCCGATGCCCAAAGCGCACTGGATGCGCACTTTGAGTTGTTGAGCGAAGACA
ATCAACCGCTACCGCGCCCGCATGCCGTCGCAGCCCATCTTGCCAAAGATGCGGGATCCTTCGAGGGAGGACAATGGCTA
TTGGTCGCTATCAATATGGATAAATTTGACGGCCGAGCCGAACGGATTAACATCACGTTGCCCCATCGCCTGTTAAGTCG
CATTGACTCTCTGGTTCGGCAACATCCGGGATACGGCAGCCGCAGCGGATTTCTCGCCGCCGCCGCGCGCAATGAATTGT
TGAAAGCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QK57

Antitoxin

Source ID Structure
AlphaFold DB A0A086GDG8

References