Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1815282..1815807 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name relE Uniprot ID A0A0N7JPE4
Locus tag AR325_RS08665 Protein ID WP_060559116.1
Coordinates 1815282..1815566 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag AR325_RS08670 Protein ID WP_004928423.1
Coordinates 1815556..1815807 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS08640 1810544..1811677 + 1134 WP_004938650.1 putrescine ABC transporter ATP-binding subunit PotG -
AR325_RS08645 1811702..1812664 + 963 WP_033633472.1 putrescine ABC transporter permease PotH -
AR325_RS08650 1812661..1813506 + 846 WP_004938644.1 putrescine ABC transporter permease PotI -
AR325_RS08655 1813611..1814096 + 486 WP_050501266.1 YbjO family protein -
AR325_RS08660 1814158..1815285 + 1128 WP_060559114.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
AR325_RS08665 1815282..1815566 - 285 WP_060559116.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AR325_RS08670 1815556..1815807 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
AR325_RS08675 1815909..1816643 - 735 WP_015377297.1 arginine ABC transporter substrate-binding protein -
AR325_RS08680 1816843..1817511 - 669 WP_004928418.1 arginine ABC transporter permease ArtM -
AR325_RS08685 1817511..1818227 - 717 WP_004928413.1 arginine ABC transporter permease ArtQ -
AR325_RS08690 1818237..1818968 - 732 WP_060559118.1 arginine ABC transporter substrate-binding protein -
AR325_RS08695 1819001..1819729 - 729 WP_004928406.1 arginine ABC transporter ATP-binding protein ArtP -
AR325_RS08700 1819992..1820534 - 543 WP_015377301.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10803.94 Da        Isoelectric Point: 10.6941

>T57822 WP_060559116.1 NZ_CP013046:c1815566-1815282 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRIMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T57822 NZ_CP013046:c1815566-1815282 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCATCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT57822 WP_004928423.1 NZ_CP013046:c1815807-1815556 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT57822 NZ_CP013046:c1815807-1815556 [Serratia marcescens]
ATGACGGTTCAACCCATTCTCGCCGACTCGGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N7JPE4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References