Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1684514..1685061 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name ccdB Uniprot ID A0A086G3V8
Locus tag AR325_RS08095 Protein ID WP_033633716.1
Coordinates 1684753..1685061 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag AR325_RS08090 Protein ID WP_033633717.1
Coordinates 1684514..1684750 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS08075 1681000..1682535 + 1536 WP_060559031.1 glutathione ABC transporter substrate-binding protein GsiB -
AR325_RS08080 1682588..1683508 + 921 WP_060559032.1 glutathione ABC transporter permease GsiC -
AR325_RS08085 1683518..1684426 + 909 WP_019454428.1 glutathione ABC transporter permease GsiD -
AR325_RS08090 1684514..1684750 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
AR325_RS08095 1684753..1685061 + 309 WP_033633716.1 CcdB family protein Toxin
AR325_RS08100 1685098..1685940 - 843 WP_015377214.1 S-formylglutathione hydrolase -
AR325_RS08105 1685955..1687079 - 1125 WP_015377215.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
AR325_RS08110 1687109..1688029 - 921 WP_004938975.1 LysR family transcriptional regulator -
AR325_RS08115 1688135..1689292 + 1158 WP_031299819.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11448.21 Da        Isoelectric Point: 5.0196

>T57821 WP_033633716.1 NZ_CP013046:1684753-1685061 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQLGKA
VGNANEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T57821 NZ_CP013046:1684753-1685061 [Serratia marcescens]
ATGCAGTTTACCGTATATGACAATACATATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGCCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGCTTATGCCCGG
AGATTGAGGTAAACGGCGAAAAGTTTCTCGTTATGACGCATGAGATGGCTGCCGTACGTATTTCACAGCTCGGGAAGGCC
GTTGGTAATGCCAATGAGCACAGGAATCAAATTAAAGCTGCCATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT57821 WP_033633717.1 NZ_CP013046:1684514-1684750 [Serratia marcescens]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT57821 NZ_CP013046:1684514-1684750 [Serratia marcescens]
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTTCGTGTCAGGGACATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGTGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086G3V8

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References