Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 570733..571304 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name relE Uniprot ID A0A0N7JP08
Locus tag AR325_RS02720 Protein ID WP_048325889.1
Coordinates 571029..571304 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag AR325_RS02715 Protein ID WP_013811307.1
Coordinates 570733..571020 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS02690 566502..567587 - 1086 WP_060558428.1 carbon-phosphorus lyase complex subunit PhnI -
AR325_RS02695 567587..568168 - 582 WP_060558429.1 phosphonate C-P lyase system protein PhnH -
AR325_RS02700 568172..568615 - 444 WP_033631646.1 phosphonate C-P lyase system protein PhnG -
AR325_RS02705 568616..569344 - 729 WP_048325886.1 phosphonate metabolism transcriptional regulator PhnF -
AR325_RS02710 569572..570627 + 1056 WP_060558431.1 permease -
AR325_RS02715 570733..571020 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AR325_RS02720 571029..571304 + 276 WP_048325889.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AR325_RS02725 571310..571774 - 465 WP_060558433.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AR325_RS02735 571943..574081 - 2139 WP_060558435.1 anaerobic ribonucleoside-triphosphate reductase -
AR325_RS02740 574326..575240 - 915 WP_060558437.1 LysR family transcriptional regulator -
AR325_RS02745 575346..575870 + 525 WP_033631652.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10722.49 Da        Isoelectric Point: 9.5103

>T57819 WP_048325889.1 NZ_CP013046:571029-571304 [Serratia marcescens]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLVNKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

>T57819 NZ_CP013046:571029-571304 [Serratia marcescens]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGCCTGCTGGATCATCCTGAATTAGGTAAGCCTTGGTATG
GGAAGGCACGTAAGCTGCTAGTTAACAAGGCCTCCCTGTTGCTGGTGTATATCATCGTCGATGATGTTATTAAGGTTTTC
TCGATTGCCCACCAGCGCGAGAAATTTCCAAACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT57819 WP_013811307.1 NZ_CP013046:570733-571020 [Serratia marcescens]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT57819 NZ_CP013046:570733-571020 [Serratia marcescens]
ATGGAAAGTCGCATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCGGAAGCTAAAGGAACGAC
ATTGAGTGAAGCCTGCCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCCGCGGAGGAGCACGAAAATTGGTTGA
AAGATAAGGTGGATGCAGCTTTTTCCCGTCTGCATGAGGGTAATGCTGTCTACCTTAGCCAACAAGAAGTAGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATTAGAGCGAAATACGACCGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N7JP08

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References