57817

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 55131..55666 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name relE Uniprot ID A0A086G6D5
Locus tag AR325_RS00245 Protein ID WP_033631416.1
Coordinates 55391..55666 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G6D4
Locus tag AR325_RS00240 Protein ID WP_033631415.1
Coordinates 55131..55391 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS00220 50455..51105 + 651 WP_060558038.1 DcrB-related protein -
AR325_RS00225 51141..51746 + 606 WP_060558041.1 glutathione S-transferase -
AR325_RS00230 51816..53210 + 1395 WP_060558042.1 L-seryl-tRNA(Sec) selenium transferase -
AR325_RS00235 53207..55048 + 1842 WP_060558044.1 selenocysteine-specific translation elongation factor -
AR325_RS00240 55131..55391 + 261 WP_033631415.1 ribbon-helix-helix domain-containing protein Antitoxin
AR325_RS00245 55391..55666 + 276 WP_033631416.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AR325_RS00250 55678..56589 - 912 WP_060558046.1 LysR family transcriptional regulator -
AR325_RS00255 56711..57337 + 627 WP_033631418.1 LysE family translocator -
AR325_RS00260 57391..58638 - 1248 WP_033633516.1 MFS transporter -
AR325_RS00265 58856..59848 + 993 WP_060558048.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.30 Da        Isoelectric Point: 10.3377

>T57817 WP_033631416.1 NZ_CP013046:55391-55666 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPAAIY
VLRIWHTREER

Download         Length: 276 bp

>T57817 NZ_CP013046:55391-55666 [Serratia marcescens]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCCCGCCTGGGTGAAAGATTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGCTATGAGATACGTTATCAGGTACAGCCGGCAGCGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9712.03 Da        Isoelectric Point: 4.5317

>AT57817 WP_033631415.1 NZ_CP013046:55131-55391 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Download         Length: 261 bp

>AT57817 NZ_CP013046:55131-55391 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCGCGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCGGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086G6D5

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6D4

References