Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 55131..55666 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name relE Uniprot ID A0A086G6D5
Locus tag AR325_RS00245 Protein ID WP_033631416.1
Coordinates 55391..55666 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G6D4
Locus tag AR325_RS00240 Protein ID WP_033631415.1
Coordinates 55131..55391 (+) Length 87 a.a.

Genomic Context

AR325_RS00220AR325_RS00225AR325_RS00230AR325_RS00235AR325_RS00240AR325_RS00245AR325_RS00255AR325_RS00265AR325_RS00250AR325_RS00260
Location: 50455..51105 (651 bp)
Type: Others
Protein ID: WP_060558038.1
Location: 51141..51746 (606 bp)
Type: Others
Protein ID: WP_060558041.1
Location: 51816..53210 (1395 bp)
Type: Others
Protein ID: WP_060558042.1
Location: 53207..55048 (1842 bp)
Type: Others
Protein ID: WP_060558044.1
Location: 55131..55391 (261 bp)
Type: Antitoxin
Protein ID: WP_033631415.1
Location: 55391..55666 (276 bp)
Type: Toxin
Protein ID: WP_033631416.1
Location: 56711..57337 (627 bp)
Type: Others
Protein ID: WP_033631418.1
Location: 58856..59848 (993 bp)
Type: Others
Protein ID: WP_060558048.1
Location: 55678..56589 (912 bp)
Type: Others
Protein ID: WP_060558046.1
Location: 57391..58638 (1248 bp)
Type: Others
Protein ID: WP_033633516.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AR325_RS0022050455..51105+651WP_060558038.1DcrB-related protein-
AR325_RS0022551141..51746+606WP_060558041.1glutathione S-transferase-
AR325_RS0023051816..53210+1395WP_060558042.1L-seryl-tRNA(Sec) selenium transferase-
AR325_RS0023553207..55048+1842WP_060558044.1selenocysteine-specific translation elongation factor-
AR325_RS0024055131..55391+261WP_033631415.1ribbon-helix-helix domain-containing proteinAntitoxin
AR325_RS0024555391..55666+276WP_033631416.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AR325_RS0025055678..56589-912WP_060558046.1LysR family transcriptional regulator-
AR325_RS0025556711..57337+627WP_033631418.1LysE family translocator-
AR325_RS0026057391..58638-1248WP_033633516.1MFS transporter-
AR325_RS0026558856..59848+993WP_060558048.1acyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.30 Da        Isoelectric Point: 10.3377

>T57817 WP_033631416.1 NZ_CP013046:55391-55666 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPAAIY
VLRIWHTREER

Download         Length: 276 bp

>T57817 NZ_CP013046:55391-55666 [Serratia marcescens]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCCCGCCTGGGTGAAAGATTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGCTATGAGATACGTTATCAGGTACAGCCGGCAGCGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9712.03 Da        Isoelectric Point: 4.5317

>AT57817 WP_033631415.1 NZ_CP013046:55131-55391 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Download         Length: 261 bp

>AT57817 NZ_CP013046:55131-55391 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCGCGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCGGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086G6D5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A086G6D4

References