Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 14211..14812 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0Q8I8
Locus tag AR325_RS00065 Protein ID WP_004933929.1
Coordinates 14211..14591 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag AR325_RS00070 Protein ID WP_004933932.1
Coordinates 14591..14812 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS00040 9457..10737 + 1281 WP_049278441.1 DUF3748 domain-containing protein -
AR325_RS00045 10768..11115 - 348 WP_004933911.1 YceK/YidQ family lipoprotein -
AR325_RS00050 11425..11838 + 414 WP_004933919.1 heat shock chaperone IbpA -
AR325_RS00055 11946..12374 + 429 WP_004933922.1 heat shock chaperone IbpB -
AR325_RS00060 12542..14200 + 1659 WP_033631397.1 putative transporter -
AR325_RS00065 14211..14591 - 381 WP_004933929.1 type II toxin-antitoxin system VapC family toxin Toxin
AR325_RS00070 14591..14812 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
AR325_RS00075 14887..16137 - 1251 WP_060558016.1 valine--pyruvate transaminase -
AR325_RS00080 16273..18336 - 2064 WP_033631398.1 alpha-amylase -
AR325_RS27210 18532..18684 + 153 WP_015376155.1 hypothetical protein -
AR325_RS00085 18686..19663 - 978 WP_060558018.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14173.48 Da        Isoelectric Point: 7.3170

>T57816 WP_004933929.1 NZ_CP013046:c14591-14211 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHTNPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T57816 NZ_CP013046:c14591-14211 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATTCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTTT
GACCGAATACCACACCAATCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAGCAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT57816 WP_004933932.1 NZ_CP013046:c14812-14591 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT57816 NZ_CP013046:c14812-14591 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGCTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0Q8I8

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References