57795

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1220136..1220754 Replicon chromosome
Accession NZ_CP013031
Organism Escherichia coli strain H1827/12

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag AB847_RS05945 Protein ID WP_001291435.1
Coordinates 1220136..1220354 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag AB847_RS05950 Protein ID WP_000344800.1
Coordinates 1220380..1220754 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB847_RS05910 1215425..1215997 + 573 WP_000779826.1 lipoprotein -
AB847_RS05915 1216028..1216339 - 312 WP_000409911.1 MGMT family protein -
AB847_RS05925 1216718..1217071 + 354 WP_000878140.1 DUF1428 domain-containing protein -
AB847_RS05930 1217113..1218663 - 1551 WP_001319841.1 cyclic-guanylate-specific phosphodiesterase PdeB -
AB847_RS05935 1218827..1219297 - 471 WP_000136192.1 YlaC family protein -
AB847_RS05940 1219413..1219964 - 552 WP_000102564.1 maltose O-acetyltransferase -
AB847_RS05945 1220136..1220354 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
AB847_RS05950 1220380..1220754 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
AB847_RS05955 1221300..1224449 - 3150 WP_065273856.1 efflux RND transporter permease AcrB -
AB847_RS05960 1224472..1225665 - 1194 WP_065273857.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T57795 WP_001291435.1 NZ_CP013031:c1220354-1220136 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T57795 NZ_CP013031:c1220354-1220136 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT57795 WP_000344800.1 NZ_CP013031:c1220754-1220380 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT57795 NZ_CP013031:c1220754-1220380 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References