Detailed information of TA system TA057791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 642114..642928
• Replicon: chromosome
• Accession: NZ_CP013031
• Organism: Escherichia coli strain H1827/12

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: AB847_RS03120
• Protein ID: WP_001054376.1
• Coordinates: 642671..642928 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: AB847_RS03115
• Protein ID: WP_001309181.1
• Coordinates: 642114..642659 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB847_RS03095	637805..639118	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
AB847_RS03100	639130..639408	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AB847_RS03105	639405..640526	-	1122	WP_000010829.1	M42 family metallopeptidase	-
AB847_RS26560	640771..640887	-	117	Protein_569	VOC family protein	-
AB847_RS25400	640925..641143	-	219	Protein_570	hypothetical protein	-
AB847_RS03110	641312..642058	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
AB847_RS03115	642114..642659	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
AB847_RS03120	642671..642928	-	258	WP_001054376.1	hypothetical protein	Toxin
AB847_RS26020	643305..643550	-	246	Protein_574	GNAT family N-acetyltransferase	-
AB847_RS03135	643666..644906	+	1241	Protein_575	helicase YjhR	-
AB847_RS03140	645489..646469	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
AB847_RS03145	646534..647640	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimD / fimF / fimG / fimH	613285..660851	47566

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T57791 WP_001054376.1 NZ_CP013031:c642928-642671 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T57791 NZ_CP013031:c642928-642671 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT57791 WP_001309181.1 NZ_CP013031:c642659-642114 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT57791 NZ_CP013031:c642659-642114 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8