Detailed information of TA system TA057767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1553384..1553865
• Replicon: chromosome
• Accession: NZ_CP013029
• Organism: Escherichia coli strain 2012C-4227

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: AKK22_RS08425
• Protein ID: WP_021568727.1
• Coordinates: 1553384..1553674 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: AKK22_RS08430
• Protein ID: WP_000108762.1
• Coordinates: 1553674..1553865 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AKK22_RS08395	1548445..1548687	-	243	WP_000273151.1	DUF4224 domain-containing protein	-
AKK22_RS08400	1548755..1551229	-	2475	WP_032206202.1	exonuclease	-
AKK22_RS08405	1551323..1551514	-	192	WP_001098307.1	DUF1482 family protein	-
AKK22_RS08410	1551511..1551699	-	189	WP_000413705.1	cell division inhibition protein DicB	-
AKK22_RS08415	1552412..1552858	+	447	WP_000373334.1	hypothetical protein	-
AKK22_RS08420	1552957..1553109	-	153	WP_000367377.1	DUF1391 family protein	-
AKK22_RS08425	1553384..1553674	-	291	WP_021568727.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AKK22_RS08430	1553674..1553865	-	192	WP_000108762.1	hypothetical protein	Antitoxin
AKK22_RS08435	1553883..1554383	-	501	WP_021568728.1	helix-turn-helix transcriptional regulator	-
AKK22_RS08440	1554491..1554754	+	264	WP_001048459.1	helix-turn-helix domain-containing protein	-
AKK22_RS08445	1554751..1555176	+	426	WP_000693918.1	Rha family transcriptional regulator	-
AKK22_RS08450	1555248..1556318	+	1071	WP_001262367.1	hypothetical protein	-
AKK22_RS08455	1556359..1556781	+	423	WP_032206198.1	DUF977 family protein	-
AKK22_RS08460	1556839..1557198	+	360	WP_032206196.1	hypothetical protein	-
AKK22_RS08465	1557244..1557456	+	213	WP_032206194.1	hypothetical protein	-
AKK22_RS08470	1557492..1558325	+	834	WP_032206192.1	hypothetical protein	-
AKK22_RS30825	1558435..1558539	+	105	WP_001278459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	espFu/tccP	1547242..1592787	45545

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11105.96 Da
• Isoelectric Point: 9.9854

>T57767 WP_021568727.1 NZ_CP013029:c1553674-1553384 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLSEHPYLYPPSERALGLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKSC

Nucleotide

• Length: 291 bp

>T57767 NZ_CP013029:c1553674-1553384 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCGCGTGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTTCTGAACATCCTTACCTGTATCCACCAAGCG
AAAGAGCTCTAGGCCTTCGTGAGATAGTGACCCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7075.91 Da
• Isoelectric Point: 4.0270

>AT57767 WP_000108762.1 NZ_CP013029:c1553865-1553674 [Escherichia coli]
MSTVLSPIISEFETIEQENSYNEWLRTKVAASLADPRPAIPHDEVMAEMENLIAQIASTNRSE

Nucleotide

• Length: 192 bp

>AT57767 NZ_CP013029:c1553865-1553674 [Escherichia coli]
ATGAGTACAGTCCTTTCCCCGATAATTTCAGAATTTGAAACAATCGAACAAGAAAACAGCTATAACGAATGGTTACGCAC
CAAAGTGGCAGCAAGCCTCGCAGACCCCCGTCCTGCAATTCCGCATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CGCAAATAGCTTCGACGAACAGGAGTGAGTAA