Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3101724..3102556 | Replicon | chromosome |
| Accession | NZ_CP013025 | ||
| Organism | Escherichia coli strain 2009C-3133 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | MJ49_RS16340 | Protein ID | WP_000854753.1 |
| Coordinates | 3101724..3102098 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | E3PJ72 |
| Locus tag | MJ49_RS16345 | Protein ID | WP_001278232.1 |
| Coordinates | 3102188..3102556 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MJ49_RS16305 | 3096792..3097397 | + | 606 | WP_001318033.1 | type II secretion system minor pseudopilin GspJ | - |
| MJ49_RS16310 | 3097394..3098371 | + | 978 | WP_000633196.1 | type II secretion system minor pseudopilin GspK | - |
| MJ49_RS16315 | 3098368..3099546 | + | 1179 | WP_000097200.1 | type II secretion system protein GspL | - |
| MJ49_RS16320 | 3099548..3100084 | + | 537 | WP_000942807.1 | GspM family type II secretion system protein YghD | - |
| MJ49_RS16325 | 3100364..3100933 | - | 570 | WP_001290247.1 | DUF4942 domain-containing protein | - |
| MJ49_RS16330 | 3101030..3101227 | - | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| MJ49_RS16335 | 3101239..3101727 | - | 489 | WP_000777541.1 | hypothetical protein | - |
| MJ49_RS16340 | 3101724..3102098 | - | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| MJ49_RS16345 | 3102188..3102556 | - | 369 | WP_001278232.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| MJ49_RS16355 | 3102719..3102940 | - | 222 | WP_001405861.1 | DUF987 domain-containing protein | - |
| MJ49_RS16360 | 3103009..3103485 | - | 477 | WP_001186724.1 | RadC family protein | - |
| MJ49_RS16365 | 3103501..3103980 | - | 480 | WP_000860065.1 | antirestriction protein | - |
| MJ49_RS16370 | 3104062..3104880 | - | 819 | WP_001234631.1 | DUF945 domain-containing protein | - |
| MJ49_RS29290 | 3104979..3105212 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| MJ49_RS16375 | 3105218..3105895 | - | 678 | WP_001097305.1 | hypothetical protein | - |
| MJ49_RS16380 | 3106043..3106723 | - | 681 | WP_001593697.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM | 3090612..3122345 | 31733 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T57737 WP_000854753.1 NZ_CP013025:c3102098-3101724 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T57737 NZ_CP013025:c3102098-3101724 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13491.37 Da Isoelectric Point: 6.6290
>AT57737 WP_001278232.1 NZ_CP013025:c3102556-3102188 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT57737 NZ_CP013025:c3102556-3102188 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LVU0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | E3PJ72 |