Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2283691..2284489 Replicon chromosome
Accession NZ_CP013025
Organism Escherichia coli strain 2009C-3133

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag MJ49_RS12195 Protein ID WP_000854735.1
Coordinates 2283691..2284068 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag MJ49_RS12200 Protein ID WP_001285415.1
Coordinates 2284115..2284489 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ49_RS12160 2279047..2279865 + 819 WP_000779405.1 lipoprotein NlpA -
MJ49_RS12165 2279869..2280792 - 924 WP_000535959.1 carboxylate/amino acid/amine transporter -
MJ49_RS12170 2280959..2281456 - 498 WP_000509808.1 hypothetical protein -
MJ49_RS12180 2282052..2282894 - 843 WP_000036706.1 DUF4942 domain-containing protein -
MJ49_RS12185 2282991..2283188 - 198 WP_000839266.1 DUF957 domain-containing protein -
MJ49_RS12190 2283206..2283694 - 489 WP_000761680.1 hypothetical protein -
MJ49_RS12195 2283691..2284068 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
MJ49_RS12200 2284115..2284489 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ49_RS12205 2284569..2284790 - 222 WP_000692309.1 DUF987 domain-containing protein -
MJ49_RS12210 2284853..2285329 - 477 WP_001366855.1 RadC family protein -
MJ49_RS12215 2285345..2285824 - 480 WP_042630954.1 antirestriction protein -
MJ49_RS12220 2285906..2286724 - 819 WP_001175149.1 DUF945 domain-containing protein -
MJ49_RS12225 2286814..2287047 - 234 WP_001278287.1 DUF905 family protein -
MJ49_RS12230 2287053..2287730 - 678 WP_001097301.1 hypothetical protein -
MJ49_RS12235 2287878..2288558 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T57727 WP_000854735.1 NZ_CP013025:c2284068-2283691 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T57727 NZ_CP013025:c2284068-2283691 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT57727 WP_001285415.1 NZ_CP013025:c2284489-2284115 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT57727 NZ_CP013025:c2284489-2284115 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References