Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1158874..1159672 Replicon chromosome
Accession NZ_CP013025
Organism Escherichia coli strain 2009C-3133

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag MJ49_RS06635 Protein ID WP_000854730.1
Coordinates 1159295..1159672 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag MJ49_RS06630 Protein ID WP_001285481.1
Coordinates 1158874..1159248 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ49_RS06590 1154849..1155301 + 453 WP_000682723.1 hypothetical protein -
MJ49_RS06595 1155419..1155652 + 234 WP_001213776.1 DUF905 family protein -
MJ49_RS06600 1155752..1156573 + 822 WP_001234359.1 DUF945 domain-containing protein -
MJ49_RS06605 1156573..1156818 + 246 WP_001164966.1 hypothetical protein -
MJ49_RS06610 1156912..1157385 + 474 WP_001313575.1 antirestriction protein -
MJ49_RS06615 1157401..1157877 + 477 WP_001313574.1 RadC family protein -
MJ49_RS06620 1157940..1158161 + 222 WP_000692315.1 DUF987 domain-containing protein -
MJ49_RS06625 1158180..1158824 + 645 WP_000086759.1 hypothetical protein -
MJ49_RS06630 1158874..1159248 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ49_RS06635 1159295..1159672 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
MJ49_RS28550 1159669..1160161 + 493 Protein_1129 hypothetical protein -
MJ49_RS06650 1160240..1161228 - 989 Protein_1130 IS630 family transposase -
MJ49_RS06655 1161376..1162969 - 1594 Protein_1131 IS66 family transposase -
MJ49_RS06660 1163000..1163350 - 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
MJ49_RS06665 1163347..1163638 - 292 Protein_1133 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T57723 WP_000854730.1 NZ_CP013025:1159295-1159672 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T57723 NZ_CP013025:1159295-1159672 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT57723 WP_001285481.1 NZ_CP013025:1158874-1159248 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT57723 NZ_CP013025:1158874-1159248 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H2V671


Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References