Detailed information of TA system TA057717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemK-mazE/MazF(toxin)
• Location: 2010216..2010842
• Replicon: chromosome
• Accession: NZ_CP013023
• Organism: Paenibacillus bovis strain BD3526

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: A0A172ZFI2
• Locus tag: AR543_RS08490
• Protein ID: WP_017812889.1
• Coordinates: 2010492..2010842 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: AR543_RS08485
• Protein ID: WP_081604101.1
• Coordinates: 2010216..2010488 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AR543_RS08475	2007730..2008215	+	486	WP_085983035.1	transcriptional repressor	-
AR543_RS08480	2008796..2009980	+	1185	WP_060533506.1	alanine racemase	-
AR543_RS08485	2010216..2010488	+	273	WP_081604101.1	antitoxin	Antitoxin
AR543_RS08490	2010492..2010842	+	351	WP_017812889.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
AR543_RS08495	2011021..2013228	+	2208	WP_179948496.1	RNA-binding transcriptional accessory protein	-
AR543_RS08500	2013478..2013843	-	366	WP_060533511.1	hypothetical protein	-
AR543_RS08505	2014060..2014545	+	486	WP_060533513.1	SprT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12929.88 Da
• Isoelectric Point: 6.4836

>T57717 WP_017812889.1 NZ_CP013023:2010492-2010842 [Paenibacillus bovis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKSHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRRVHDSLQISLGLVDF

Nucleotide

• Length: 351 bp

>T57717 NZ_CP013023:2010492-2010842 [Paenibacillus bovis]
TTGATCGTAAAGCGCGGCGATGTATTTTTTGCAGATTTATCGCCCGTCGTCGGTTCCGAACAGGGTGGCGTAAGACCGGT
TTTGGTAATCCAGAACGACATTGGTAATCGCTTCAGTCCGACGGTCATTGTGGCGGCAATTACGGCACAGATCCAGAAGG
CCAAATTGCCGACGCACGTGGAAATTGACGCCAAATCCCACGGGTTTGACAGGGATTCCGTCATTTTATTAGAGCAGATT
CGTACCATTGACAAGCAGCGTTTAACTGACAAAATCACACATCTGGATGAGGAGACCATGCGTCGTGTGCATGACTCGCT
CCAGATTAGCCTGGGCCTGGTAGATTTCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10396.03 Da
• Isoelectric Point: 5.7302

>AT57717 WP_081604101.1 NZ_CP013023:2010216-2010488 [Paenibacillus bovis]
MQNVQGIMVHLPDQLLQEMDGIAALENSDRNELIRKAMKGYLTERKKRHVREAMQRGYMEMAKINLRIACEAFYAEEEAD
ITLDRLVSGV

Nucleotide

• Length: 273 bp

>AT57717 NZ_CP013023:2010216-2010488 [Paenibacillus bovis]
ATGCAAAATGTGCAAGGGATTATGGTCCATTTACCGGATCAGCTTTTGCAGGAGATGGATGGGATCGCAGCGTTGGAGAA
TTCCGACCGCAACGAGTTAATCAGAAAAGCCATGAAAGGGTATCTTACCGAGCGCAAGAAGCGGCATGTCCGCGAAGCAA
TGCAACGTGGATACATGGAAATGGCCAAGATCAATCTGAGAATCGCTTGTGAAGCTTTTTATGCGGAGGAAGAGGCGGAT
ATCACTCTGGACCGCTTAGTTAGCGGGGTGTAG

Structures

Toxin

• AlphaFold DB: A0A172ZFI2