Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 889720..890298 | Replicon | chromosome |
| Accession | NZ_CP013013 | ||
| Organism | Vibrio cholerae strain Env-390 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | AP033_RS04160 | Protein ID | WP_001180243.1 |
| Coordinates | 889981..890298 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | AP033_RS04155 | Protein ID | WP_000557292.1 |
| Coordinates | 889720..889962 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AP033_RS19215 | 885136..885306 | - | 171 | WP_001882300.1 | DUF645 family protein | - |
| AP033_RS20055 | 885501..885611 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| AP033_RS04130 | 885608..885925 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| AP033_RS04135 | 885936..886223 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AP033_RS19230 | 886490..886670 | - | 181 | Protein_817 | DUF645 family protein | - |
| AP033_RS19235 | 887095..887328 | - | 234 | Protein_818 | DUF3709 domain-containing protein | - |
| AP033_RS04140 | 887731..887949 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| AP033_RS04145 | 888259..888912 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| AP033_RS04150 | 888969..889478 | - | 510 | WP_000405986.1 | GNAT family N-acetyltransferase | - |
| AP033_RS04155 | 889720..889962 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AP033_RS04160 | 889981..890298 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AP033_RS19245 | 890313..890435 | - | 123 | WP_080033517.1 | DUF3265 domain-containing protein | - |
| AP033_RS04165 | 890457..890675 | - | 219 | WP_001209280.1 | hypothetical protein | - |
| AP033_RS04170 | 890918..891328 | - | 411 | WP_000734967.1 | hypothetical protein | - |
| AP033_RS04175 | 891469..891984 | - | 516 | WP_000343781.1 | GNAT family N-acetyltransferase | - |
| AP033_RS04180 | 892128..892577 | - | 450 | WP_001026798.1 | GyrI-like domain-containing protein | - |
| AP033_RS04185 | 892740..892976 | - | 237 | WP_001059493.1 | hypothetical protein | - |
| AP033_RS04190 | 893219..893719 | - | 501 | WP_000686370.1 | NAD(P)H-dependent oxidoreductase | - |
| AP033_RS19250 | 893978..894211 | - | 234 | WP_080004228.1 | DUF3709 domain-containing protein | - |
| AP033_RS04195 | 894483..894965 | - | 483 | WP_000422943.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 829699..942463 | 112764 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T57713 WP_001180243.1 NZ_CP013013:889981-890298 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T57713 NZ_CP013013:889981-890298 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT57713 WP_000557292.1 NZ_CP013013:889720-889962 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT57713 NZ_CP013013:889720-889962 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |