Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 868071..868636 | Replicon | chromosome |
| Accession | NZ_CP013013 | ||
| Organism | Vibrio cholerae strain Env-390 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | AP033_RS04015 | Protein ID | WP_000869999.1 |
| Coordinates | 868071..868358 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | AP033_RS04020 | Protein ID | WP_000086649.1 |
| Coordinates | 868355..868636 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AP033_RS03975 | 863470..863985 | - | 516 | WP_001201532.1 | lipocalin family protein | - |
| AP033_RS19125 | 864012..864104 | - | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
| AP033_RS03980 | 864126..864704 | - | 579 | WP_000110120.1 | hypothetical protein | - |
| AP033_RS03985 | 864933..865175 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| AP033_RS03990 | 865172..865471 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AP033_RS03995 | 865602..866117 | - | 516 | WP_000100089.1 | ClbS/DfsB family four-helix bundle protein | - |
| AP033_RS04000 | 866312..866494 | - | 183 | WP_001889223.1 | DUF645 family protein | - |
| AP033_RS04005 | 866789..867238 | - | 450 | WP_000480555.1 | hypothetical protein | - |
| AP033_RS04010 | 867373..867912 | - | 540 | WP_000884561.1 | hydrolase | - |
| AP033_RS04015 | 868071..868358 | - | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AP033_RS04020 | 868355..868636 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AP033_RS04025 | 868850..869275 | - | 426 | WP_000735184.1 | hypothetical protein | - |
| AP033_RS19150 | 870094..870375 | - | 282 | WP_080033523.1 | DUF1289 domain-containing protein | - |
| AP033_RS20040 | 870324..870437 | - | 114 | WP_080033520.1 | acetyltransferase | - |
| AP033_RS04030 | 870494..871045 | - | 552 | WP_001008561.1 | VRR-NUC domain-containing protein | - |
| AP033_RS19160 | 871316..871639 | - | 324 | WP_080033519.1 | DUF3709 domain-containing protein | - |
| AP033_RS04035 | 871771..872439 | - | 669 | WP_000852842.1 | hypothetical protein | - |
| AP033_RS04040 | 872597..872959 | - | 363 | WP_170831679.1 | DUF4144 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 829699..942463 | 112764 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T57711 WP_000869999.1 NZ_CP013013:c868358-868071 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T57711 NZ_CP013013:c868358-868071 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT57711 WP_000086649.1 NZ_CP013013:c868636-868355 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT57711 NZ_CP013013:c868636-868355 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |