Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 864933..865471 Replicon chromosome
Accession NZ_CP013013
Organism Vibrio cholerae strain Env-390

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag AP033_RS03990 Protein ID WP_000802136.1
Coordinates 865172..865471 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag AP033_RS03985 Protein ID WP_001107719.1
Coordinates 864933..865175 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AP033_RS03945 860298..860828 - 531 WP_000415563.1 hypothetical protein -
AP033_RS03950 860979..861374 - 396 WP_000649527.1 DUF3465 domain-containing protein -
AP033_RS03955 861582..862007 - 426 WP_000415748.1 hypothetical protein -
AP033_RS03960 862275..862610 - 336 WP_000332173.1 hypothetical protein -
AP033_RS03965 862806..863054 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AP033_RS03970 863044..863334 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
AP033_RS03975 863470..863985 - 516 WP_001201532.1 lipocalin family protein -
AP033_RS19125 864012..864104 - 93 WP_014164112.1 DUF3265 domain-containing protein -
AP033_RS03980 864126..864704 - 579 WP_000110120.1 hypothetical protein -
AP033_RS03985 864933..865175 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AP033_RS03990 865172..865471 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AP033_RS03995 865602..866117 - 516 WP_000100089.1 ClbS/DfsB family four-helix bundle protein -
AP033_RS04000 866312..866494 - 183 WP_001889223.1 DUF645 family protein -
AP033_RS04005 866789..867238 - 450 WP_000480555.1 hypothetical protein -
AP033_RS04010 867373..867912 - 540 WP_000884561.1 hydrolase -
AP033_RS04015 868071..868358 - 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin -
AP033_RS04020 868355..868636 - 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AP033_RS04025 868850..869275 - 426 WP_000735184.1 hypothetical protein -
AP033_RS19150 870094..870375 - 282 WP_080033523.1 DUF1289 domain-containing protein -
AP033_RS20040 870324..870437 - 114 WP_080033520.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 829699..942463 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T57710 WP_000802136.1 NZ_CP013013:865172-865471 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T57710 NZ_CP013013:865172-865471 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT57710 WP_001107719.1 NZ_CP013013:864933-865175 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT57710 NZ_CP013013:864933-865175 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References