Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2187406..2187977 Replicon chromosome
Accession NZ_CP013009
Organism Enterococcus faecium strain UW7606x64/3 TC1

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag AQ614_RS10720 Protein ID WP_002286801.1
Coordinates 2187406..2187747 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag AQ614_RS10725 Protein ID WP_002323011.1
Coordinates 2187747..2187977 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ614_RS10700 2182979..2183872 - 894 WP_002286772.1 class C sortase -
AQ614_RS10705 2183946..2185547 - 1602 Protein_2040 SpaH/EbpB family LPXTG-anchored major pilin -
AQ614_RS10720 2187406..2187747 - 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AQ614_RS10725 2187747..2187977 - 231 WP_002323011.1 hypothetical protein Antitoxin
AQ614_RS10730 2188264..2188602 + 339 WP_002286804.1 hypothetical protein -
AQ614_RS10735 2188807..2189382 - 576 WP_002293673.1 SOS response-associated peptidase family protein -
AQ614_RS10740 2189868..2190449 - 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
AQ614_RS10745 2190632..2191258 - 627 WP_002286816.1 cysteine hydrolase -
AQ614_RS10750 2191280..2192611 - 1332 WP_002330022.1 FAD-containing oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T57697 WP_002286801.1 NZ_CP013009:c2187747-2187406 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

>T57697 NZ_CP013009:c2187747-2187406 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT57697 WP_002323011.1 NZ_CP013009:c2187977-2187747 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp

>AT57697 NZ_CP013009:c2187977-2187747 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References