Detailed information of TA system TA057693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2835896..2836452
• Replicon: chromosome
• Accession: NZ_CP013006
• Organism: Xanthomonas citri pv. malvacearum strain XcmN1003

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: APY30_RS13005
• Protein ID: WP_033836591.1
• Coordinates: 2835896..2836186 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: APY30_RS13010
• Protein ID: WP_004541313.1
• Coordinates: 2836174..2836452 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APY30_RS12990	2834381..2834916	-	536	Protein_2408	transposase	-
APY30_RS12995	2835129..2835308	-	180	WP_015463309.1	hypothetical protein	-
APY30_RS13000	2835579..2835899	-	321	WP_099522003.1	hypothetical protein	-
APY30_RS13005	2835896..2836186	-	291	WP_033836591.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
APY30_RS13010	2836174..2836452	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
APY30_RS13015	2836533..2836965	-	433	Protein_2413	relaxase	-
APY30_RS24270	2836937..2837098	-	162	WP_108350140.1	hypothetical protein	-
APY30_RS13020	2837174..2838330	+	1157	WP_087942126.1	IS3-like element ISXc8 family transposase	-
APY30_RS13025	2838834..2839049	+	216	Protein_2416	SAM-dependent DNA methyltransferase	-
APY30_RS13035	2839572..2840659	+	1088	WP_087943923.1	IS3-like element ISXac2 family transposase	-
APY30_RS24830	2840746..2840913	+	168	WP_005913009.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2827347..2837461	10114
	-	inside	IScluster/Tn	-	-	2829076..2840659	11583

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10858.43 Da
• Isoelectric Point: 9.9308

>T57693 WP_033836591.1 NZ_CP013006:c2836186-2835896 [Xanthomonas citri pv. malvacearum]
MPQVIFAPAAIGDMQRLREFLKPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T57693 NZ_CP013006:c2836186-2835896 [Xanthomonas citri pv. malvacearum]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT57693 WP_004541313.1 NZ_CP013006:c2836452-2836174 [Xanthomonas citri pv. malvacearum]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT57693 NZ_CP013006:c2836452-2836174 [Xanthomonas citri pv. malvacearum]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGTGAGGCGTTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACGGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACAGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0