Detailed information of TA system TA057682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 1123493..1123926
• Replicon: chromosome
• Accession: NZ_CP013002
• Organism: Caulobacter henricii strain CB4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AQ619_RS18675
• Protein ID: WP_084745767.1
• Coordinates: 1123660..1123926 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0P0P3S4
• Locus tag: AQ619_RS05265
• Protein ID: WP_062145182.1
• Coordinates: 1123493..1123672 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AQ619_RS05245	1119766..1121010	+	1245	WP_062145177.1	DUF1254 domain-containing protein	-
AQ619_RS05250	1121014..1122123	+	1110	WP_062145178.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
AQ619_RS05255	1122123..1122599	+	477	WP_062145179.1	hypothetical protein	-
AQ619_RS05260	1122607..1123440	+	834	WP_062145180.1	S-formylglutathione hydrolase	-
AQ619_RS05265	1123493..1123672	+	180	WP_062145182.1	hypothetical protein	Antitoxin
AQ619_RS18675	1123660..1123926	+	267	WP_084745767.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AQ619_RS05270	1124003..1124377	+	375	WP_062145184.1	hypothetical protein	-
AQ619_RS05275	1124557..1125174	+	618	WP_062145186.1	30S ribosomal protein S4	-
AQ619_RS05280	1125687..1126028	+	342	WP_062145188.1	zf-TFIIB domain-containing protein	-
AQ619_RS05285	1126039..1126968	+	930	WP_062145190.1	zinc metalloprotease HtpX	-
AQ619_RS05290	1127170..1127526	+	357	WP_062145192.1	hypothetical protein	-
AQ619_RS05295	1127539..1127958	-	420	WP_062145194.1	acyl-CoA thioesterase	-
AQ619_RS05300	1127955..1128296	-	342	WP_062145196.1	Grx4 family monothiol glutaredoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9994.69 Da
• Isoelectric Point: 12.1064

>T57682 WP_084745767.1 NZ_CP013002:1123660-1123926 [Caulobacter henricii]
VAEVVWSRRALSDLFAIRAYIGQFSPLAAQRMARRLRVAGDSLVNHPDRGRLVTATIRELVVISPYIIRYQITGDRVNVI
RIRHAAQL

Nucleotide

• Length: 267 bp

>T57682 NZ_CP013002:1123660-1123926 [Caulobacter henricii]
GTGGCTGAAGTAGTCTGGTCGCGTCGGGCGCTTTCCGACCTATTCGCAATCCGGGCCTATATTGGCCAATTCAGCCCTCT
CGCCGCGCAGCGCATGGCTCGCAGGCTTCGGGTGGCCGGGGACAGTCTTGTGAACCACCCTGATCGGGGTCGTCTGGTCA
CAGCGACCATACGGGAGCTGGTGGTCATTTCGCCCTACATCATCCGCTATCAGATCACGGGCGATCGGGTGAACGTCATC
CGTATCCGGCACGCCGCCCAGTTGTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6291.97 Da
• Isoelectric Point: 3.7320

>AT57682 WP_062145182.1 NZ_CP013002:1123493-1123672 [Caulobacter henricii]
MVPEPSIFDEVDAASEEAADAEGLADIAAGRVVPHAEVSAWLETWGTPDEKPMPASWLK

Nucleotide

• Length: 180 bp

>AT57682 NZ_CP013002:1123493-1123672 [Caulobacter henricii]
ATGGTTCCTGAGCCCTCCATCTTCGATGAGGTGGACGCCGCCAGCGAAGAGGCTGCGGACGCCGAAGGTCTGGCTGACAT
CGCCGCAGGCCGGGTGGTACCCCATGCAGAAGTCTCGGCCTGGCTTGAGACTTGGGGCACGCCAGATGAGAAACCCATGC
CTGCGTCGTGGCTGAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0P0P3S4