Detailed information of TA system TA057681

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 399480..400186
• Replicon: chromosome
• Accession: NZ_CP013002
• Organism: Caulobacter henricii strain CB4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0P0NWJ9
• Locus tag: AQ619_RS01945
• Protein ID: WP_062143512.1
• Coordinates: 399480..399932 (-)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AQ619_RS01950
• Protein ID: WP_207205011.1
• Coordinates: 399929..400186 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AQ619_RS01920	394613..397045	+	2433	WP_062143499.1	M1 family metallopeptidase	-
AQ619_RS01925	397042..397569	+	528	WP_062143502.1	hypothetical protein	-
AQ619_RS01930	397592..398143	-	552	WP_062143506.1	hypothetical protein	-
AQ619_RS01935	398149..398556	-	408	WP_166504115.1	dihydroneopterin aldolase	-
AQ619_RS01940	398571..399323	-	753	WP_062143509.1	SDR family oxidoreductase	-
AQ619_RS01945	399480..399932	-	453	WP_062143512.1	type II toxin-antitoxin system VapC family toxin	Toxin
AQ619_RS01950	399929..400186	-	258	WP_207205011.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AQ619_RS01955	400263..400733	+	471	WP_062151171.1	NUDIX domain-containing protein	-
AQ619_RS01960	400838..402277	+	1440	WP_062143519.1	aldehyde dehydrogenase family protein	-
AQ619_RS01965	402665..403108	+	444	WP_062143522.1	GNAT family N-acetyltransferase	-
AQ619_RS01970	403368..404300	-	933	WP_062143525.1	CPBP family intramembrane metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-127)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-60)

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 16150.34 Da
• Isoelectric Point: 7.4028

>T57681 WP_062143512.1 NZ_CP013002:c399932-399480 [Caulobacter henricii]
VKGWLVDTNVIAALINPNGAPSVKAWAAGQPEARMFISVLSLGEYDKGIHNLATDHPDRSRYIAARDALAGRFAGRVLSV
SDPVVRRWGKISGAVKLRTGHAPSVIDTLLAATALEHDLFLVTRNTRDVQDSGAPLFNPWTDDPADFPLA

Nucleotide

• Length: 453 bp

>T57681 NZ_CP013002:c399932-399480 [Caulobacter henricii]
GTGAAGGGCTGGCTGGTCGACACCAATGTCATCGCCGCCCTGATCAATCCGAACGGCGCTCCCAGCGTCAAGGCCTGGGC
CGCAGGTCAGCCGGAGGCGCGGATGTTCATCAGCGTTCTGTCGCTGGGCGAATACGACAAGGGCATCCACAACCTGGCGA
CCGATCATCCCGACCGCTCGCGCTATATCGCCGCTCGCGACGCCCTGGCCGGGCGGTTCGCCGGACGGGTCCTGTCGGTC
AGCGATCCGGTGGTGCGCCGCTGGGGCAAGATCTCGGGCGCGGTGAAGCTGCGCACGGGTCACGCGCCGTCGGTGATCGA
CACCCTGCTGGCGGCCACGGCCCTGGAACACGACCTGTTTCTGGTCACCCGCAACACCCGCGACGTCCAGGACAGCGGCG
CGCCGCTATTCAATCCCTGGACCGACGATCCTGCCGATTTTCCTTTGGCGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9456.72 Da
• Isoelectric Point: 4.5141

>AT57681 WP_207205011.1 NZ_CP013002:c400186-399929 [Caulobacter henricii]
MGDLSWKLEDAKARFSEVVRLARSQGPQRVTVRGKDAVVVMSIEDLERLSPPDPARLSLVSFLEGLHLDGLDVEREPDSG
RDLDL

Nucleotide

• Length: 258 bp

>AT57681 NZ_CP013002:c400186-399929 [Caulobacter henricii]
ATGGGCGATCTCAGCTGGAAACTGGAAGACGCCAAGGCCCGCTTCAGCGAGGTGGTGCGTCTGGCCCGCAGCCAGGGCCC
GCAAAGGGTGACCGTGCGCGGCAAGGACGCCGTGGTGGTGATGAGCATCGAGGATCTTGAACGCCTGTCGCCGCCCGATC
CGGCCCGTCTGTCGCTGGTCTCGTTTCTGGAAGGCCTGCATCTGGATGGGCTCGATGTGGAGCGCGAACCCGATTCTGGG
CGAGATCTCGACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0P0NWJ9