Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3912189..3912846 Replicon chromosome
Accession NZ_CP012999
Organism Enterobacter sp. E20

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag NI40_RS18150 Protein ID WP_021242050.1
Coordinates 3912189..3912599 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag NI40_RS18155 Protein ID WP_010435322.1
Coordinates 3912580..3912846 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI40_RS18130 3908182..3909915 - 1734 WP_039262981.1 single-stranded-DNA-specific exonuclease RecJ -
NI40_RS18135 3909921..3910634 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NI40_RS18140 3910663..3911559 - 897 WP_039262980.1 site-specific tyrosine recombinase XerD -
NI40_RS18145 3911661..3912182 + 522 WP_039262979.1 flavodoxin FldB -
NI40_RS18150 3912189..3912599 - 411 WP_021242050.1 protein YgfX Toxin
NI40_RS18155 3912580..3912846 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
NI40_RS18160 3913141..3914121 + 981 WP_039262978.1 tRNA-modifying protein YgfZ -
NI40_RS18165 3914186..3914845 - 660 WP_033146591.1 hemolysin III family protein -
NI40_RS18170 3915011..3915322 - 312 WP_033146592.1 N(4)-acetylcytidine aminohydrolase -
NI40_RS18175 3915374..3916105 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
NI40_RS18180 3916222..3917655 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T57679 WP_021242050.1 NZ_CP012999:c3912599-3912189 [Enterobacter sp. E20]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T57679 NZ_CP012999:c3912599-3912189 [Enterobacter sp. E20]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGGGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT57679 WP_010435322.1 NZ_CP012999:c3912846-3912580 [Enterobacter sp. E20]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT57679 NZ_CP012999:c3912846-3912580 [Enterobacter sp. E20]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References