Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 254769..255365 Replicon chromosome
Accession NZ_CP012999
Organism Enterobacter sp. E20

Toxin (Protein)


Gene name PumA Uniprot ID A0A4R0G5K0
Locus tag NI40_RS01125 Protein ID WP_039264167.1
Coordinates 255063..255365 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A808IFF3
Locus tag NI40_RS01120 Protein ID WP_033144375.1
Coordinates 254769..255056 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI40_RS01115 253141..254772 + 1632 WP_039264168.1 Na/Pi cotransporter family protein -
NI40_RS01120 254769..255056 - 288 WP_033144375.1 putative addiction module antidote protein Antitoxin
NI40_RS01125 255063..255365 - 303 WP_039264167.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NI40_RS01130 255563..256435 + 873 WP_039264166.1 23S rRNA pseudouridine(2604) synthase RluF -
NI40_RS01135 256436..256708 - 273 WP_023309994.1 DUF3811 domain-containing protein -
NI40_RS01140 256759..257703 - 945 WP_039264165.1 ketopantoate/pantoate/pantothenate transporter PanS -
NI40_RS01145 257797..259146 - 1350 WP_039264164.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11401.17 Da        Isoelectric Point: 9.6038

>T57668 WP_039264167.1 NZ_CP012999:c255365-255063 [Enterobacter sp. E20]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPVGEGISELRIHYGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T57668 NZ_CP012999:c255365-255063 [Enterobacter sp. E20]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAAACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTGGGCGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTACAGAATCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10111.59 Da        Isoelectric Point: 6.4596

>AT57668 WP_033144375.1 NZ_CP012999:c255056-254769 [Enterobacter sp. E20]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAGD

Download         Length: 288 bp

>AT57668 NZ_CP012999:c255056-254769 [Enterobacter sp. E20]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCGCTGGGCGTCATCGCGCGCGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCTGGAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0G5K0

Antitoxin

Source ID Structure
AlphaFold DB A0A808IFF3

References