Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 888522..889100 Replicon chromosome
Accession NZ_CP012997
Organism Vibrio cholerae strain 2012Env-9

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag NH62_RS04150 Protein ID WP_001180243.1
Coordinates 888783..889100 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag NH62_RS04145 Protein ID WP_000557292.1
Coordinates 888522..888764 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NH62_RS19265 883938..884108 - 171 WP_001882300.1 DUF645 family protein -
NH62_RS20385 884303..884413 - 111 WP_134814058.1 DUF3265 domain-containing protein -
NH62_RS04120 884410..884727 - 318 WP_001232701.1 HigA family addiction module antidote protein -
NH62_RS04125 884738..885025 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
NH62_RS19280 885292..885472 - 181 Protein_815 DUF645 family protein -
NH62_RS19285 885897..886130 - 234 Protein_816 DUF3709 domain-containing protein -
NH62_RS04130 886533..886751 - 219 WP_001917086.1 DUF3709 domain-containing protein -
NH62_RS04135 887061..887714 - 654 WP_000226874.1 hypothetical protein -
NH62_RS04140 887771..888280 - 510 WP_000405986.1 GNAT family N-acetyltransferase -
NH62_RS04145 888522..888764 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NH62_RS04150 888783..889100 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NH62_RS19295 889115..889237 - 123 WP_080033517.1 DUF3265 domain-containing protein -
NH62_RS04155 889259..889477 - 219 WP_001209280.1 hypothetical protein -
NH62_RS04160 889720..890130 - 411 WP_000734967.1 hypothetical protein -
NH62_RS04165 890271..890786 - 516 WP_000343781.1 GNAT family N-acetyltransferase -
NH62_RS04170 890930..891379 - 450 WP_001026798.1 GyrI-like domain-containing protein -
NH62_RS04175 891542..891778 - 237 WP_001059493.1 hypothetical protein -
NH62_RS04180 892021..892521 - 501 WP_000686370.1 NAD(P)H-dependent oxidoreductase -
NH62_RS19300 892780..893013 - 234 WP_080004228.1 DUF3709 domain-containing protein -
NH62_RS04185 893285..893767 - 483 WP_000422943.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827256..947647 120391
- inside Integron - - 828501..941266 112765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T57666 WP_001180243.1 NZ_CP012997:888783-889100 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T57666 NZ_CP012997:888783-889100 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT57666 WP_000557292.1 NZ_CP012997:888522-888764 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT57666 NZ_CP012997:888522-888764 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References