Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 866873..867438 | Replicon | chromosome |
| Accession | NZ_CP012997 | ||
| Organism | Vibrio cholerae strain 2012Env-9 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | NH62_RS04005 | Protein ID | WP_000869999.1 |
| Coordinates | 866873..867160 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | NH62_RS04010 | Protein ID | WP_000086649.1 |
| Coordinates | 867157..867438 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NH62_RS03965 | 862272..862787 | - | 516 | WP_001201532.1 | lipocalin family protein | - |
| NH62_RS19175 | 862814..862906 | - | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
| NH62_RS03970 | 862928..863506 | - | 579 | WP_000110120.1 | hypothetical protein | - |
| NH62_RS03975 | 863735..863977 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| NH62_RS03980 | 863974..864273 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| NH62_RS03985 | 864404..864919 | - | 516 | WP_000100089.1 | ClbS/DfsB family four-helix bundle protein | - |
| NH62_RS03990 | 865114..865296 | - | 183 | WP_001889223.1 | DUF645 family protein | - |
| NH62_RS03995 | 865591..866040 | - | 450 | WP_000480555.1 | hypothetical protein | - |
| NH62_RS04000 | 866175..866714 | - | 540 | WP_000884561.1 | hydrolase | - |
| NH62_RS04005 | 866873..867160 | - | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| NH62_RS04010 | 867157..867438 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| NH62_RS04015 | 867652..868077 | - | 426 | WP_000735184.1 | hypothetical protein | - |
| NH62_RS19200 | 868896..869177 | - | 282 | WP_080033523.1 | DUF1289 domain-containing protein | - |
| NH62_RS20365 | 869126..869239 | - | 114 | WP_080033520.1 | acetyltransferase | - |
| NH62_RS04020 | 869296..869847 | - | 552 | WP_001008561.1 | VRR-NUC domain-containing protein | - |
| NH62_RS19210 | 870118..870441 | - | 324 | WP_080033519.1 | DUF3709 domain-containing protein | - |
| NH62_RS04025 | 870573..871241 | - | 669 | WP_000852842.1 | hypothetical protein | - |
| NH62_RS04030 | 871399..871761 | - | 363 | WP_170831679.1 | DUF4144 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 827256..947647 | 120391 | |
| - | inside | Integron | - | - | 828501..941266 | 112765 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T57664 WP_000869999.1 NZ_CP012997:c867160-866873 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T57664 NZ_CP012997:c867160-866873 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT57664 WP_000086649.1 NZ_CP012997:c867438-867157 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT57664 NZ_CP012997:c867438-867157 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |