Detailed information of TA system TA057662

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 861608..862136
• Replicon: chromosome
• Accession: NZ_CP012997
• Organism: Vibrio cholerae strain 2012Env-9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H9L4R3
• Locus tag: NH62_RS03960
• Protein ID: WP_000221352.1
• Coordinates: 861846..862136 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H9L4T4
• Locus tag: NH62_RS03955
• Protein ID: WP_000213183.1
• Coordinates: 861608..861856 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NH62_RS03920	857344..857808	+	465	WP_000140244.1	hypothetical protein	-
NH62_RS03925	857908..858306	-	399	WP_001882293.1	hypothetical protein	-
NH62_RS03930	858462..858962	-	501	WP_000789723.1	hypothetical protein	-
NH62_RS03935	859100..859630	-	531	WP_000415563.1	hypothetical protein	-
NH62_RS03940	859781..860176	-	396	WP_000649527.1	DUF3465 domain-containing protein	-
NH62_RS03945	860384..860809	-	426	WP_000415748.1	hypothetical protein	-
NH62_RS03950	861077..861412	-	336	WP_000332173.1	hypothetical protein	-
NH62_RS03955	861608..861856	+	249	WP_000213183.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
NH62_RS03960	861846..862136	+	291	WP_000221352.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NH62_RS03965	862272..862787	-	516	WP_001201532.1	lipocalin family protein	-
NH62_RS19175	862814..862906	-	93	WP_014164112.1	DUF3265 domain-containing protein	-
NH62_RS03970	862928..863506	-	579	WP_000110120.1	hypothetical protein	-
NH62_RS03975	863735..863977	+	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
NH62_RS03980	863974..864273	+	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NH62_RS03985	864404..864919	-	516	WP_000100089.1	ClbS/DfsB family four-helix bundle protein	-
NH62_RS03990	865114..865296	-	183	WP_001889223.1	DUF645 family protein	-
NH62_RS03995	865591..866040	-	450	WP_000480555.1	hypothetical protein	-
NH62_RS04000	866175..866714	-	540	WP_000884561.1	hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	827256..947647	120391
	-	inside	Integron	-	-	828501..941266	112765

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11247.23 Da
• Isoelectric Point: 10.4678

>T57662 WP_000221352.1 NZ_CP012997:861846-862136 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Nucleotide

• Length: 291 bp

>T57662 NZ_CP012997:861846-862136 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8937.28 Da
• Isoelectric Point: 4.1079

>AT57662 WP_000213183.1 NZ_CP012997:861608-861856 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Nucleotide

• Length: 249 bp

>AT57662 NZ_CP012997:861608-861856 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: H9L4R3

Antitoxin

• AlphaFold DB: A0A366A3W8