Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3606295..3606952 Replicon chromosome
Accession NZ_CP012992
Organism Klebsiella pneumoniae strain KpN06

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AQD73_RS18030 Protein ID WP_002916310.1
Coordinates 3606542..3606952 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AQD73_RS18025 Protein ID WP_002916312.1
Coordinates 3606295..3606561 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQD73_RS18000 3601451..3602884 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
AQD73_RS18005 3603003..3603731 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
AQD73_RS18010 3603781..3604092 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AQD73_RS18015 3604256..3604915 + 660 WP_002916317.1 hemolysin III family protein -
AQD73_RS18020 3605066..3606049 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AQD73_RS18025 3606295..3606561 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AQD73_RS18030 3606542..3606952 + 411 WP_002916310.1 protein YgfX Toxin
AQD73_RS18035 3606959..3607480 - 522 WP_004144730.1 flavodoxin FldB -
AQD73_RS18040 3607581..3608477 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AQD73_RS18045 3608500..3609213 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AQD73_RS18050 3609219..3610952 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T57638 WP_002916310.1 NZ_CP012992:3606542-3606952 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T57638 NZ_CP012992:3606542-3606952 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGTTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT57638 WP_002916312.1 NZ_CP012992:3606295-3606561 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT57638 NZ_CP012992:3606295-3606561 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References