Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2221086..2221602 Replicon chromosome
Accession NZ_CP012992
Organism Klebsiella pneumoniae strain KpN06

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag AQD73_RS11005 Protein ID WP_004178374.1
Coordinates 2221086..2221370 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag AQD73_RS11010 Protein ID WP_004192397.1
Coordinates 2221360..2221602 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQD73_RS10975 2216482..2216790 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
AQD73_RS31195 2216875..2217048 + 174 WP_002886906.1 hypothetical protein -
AQD73_RS10985 2217051..2217794 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AQD73_RS10995 2218151..2220289 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AQD73_RS11000 2220618..2221082 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AQD73_RS11005 2221086..2221370 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQD73_RS11010 2221360..2221602 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AQD73_RS11015 2221680..2223590 - 1911 WP_004152270.1 BglG family transcription antiterminator -
AQD73_RS11020 2223613..2224767 - 1155 WP_004178372.1 lactonase family protein -
AQD73_RS11025 2224834..2225574 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T57633 WP_004178374.1 NZ_CP012992:c2221370-2221086 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T57633 NZ_CP012992:c2221370-2221086 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT57633 WP_004192397.1 NZ_CP012992:c2221602-2221360 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT57633 NZ_CP012992:c2221602-2221360 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References