Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1490138..1490757 Replicon chromosome
Accession NZ_CP012992
Organism Klebsiella pneumoniae strain KpN06

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AQD73_RS07475 Protein ID WP_002892050.1
Coordinates 1490539..1490757 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag AQD73_RS07470 Protein ID WP_002892066.1
Coordinates 1490138..1490512 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQD73_RS07460 1485290..1486483 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AQD73_RS07465 1486506..1489652 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
AQD73_RS07470 1490138..1490512 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
AQD73_RS07475 1490539..1490757 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AQD73_RS07480 1490916..1491482 + 567 WP_002892030.1 maltose O-acetyltransferase -
AQD73_RS31125 1491454..1491594 - 141 WP_004147370.1 hypothetical protein -
AQD73_RS07490 1491615..1492085 + 471 WP_032431532.1 YlaC family protein -
AQD73_RS07495 1492060..1493511 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
AQD73_RS07500 1493612..1494310 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
AQD73_RS07505 1494307..1494447 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
AQD73_RS07510 1494447..1494710 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T57631 WP_002892050.1 NZ_CP012992:1490539-1490757 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T57631 NZ_CP012992:1490539-1490757 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT57631 WP_002892066.1 NZ_CP012992:1490138-1490512 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT57631 NZ_CP012992:1490138-1490512 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAGGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References