Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3614690..3615347 Replicon chromosome
Accession NZ_CP012987
Organism Klebsiella pneumoniae strain KpN01

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AQD68_RS18080 Protein ID WP_002916310.1
Coordinates 3614937..3615347 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AQD68_RS18075 Protein ID WP_002916312.1
Coordinates 3614690..3614956 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQD68_RS18050 3609846..3611279 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
AQD68_RS18055 3611398..3612126 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
AQD68_RS18060 3612176..3612487 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AQD68_RS18065 3612651..3613310 + 660 WP_002916317.1 hemolysin III family protein -
AQD68_RS18070 3613461..3614444 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AQD68_RS18075 3614690..3614956 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AQD68_RS18080 3614937..3615347 + 411 WP_002916310.1 protein YgfX Toxin
AQD68_RS18085 3615354..3615875 - 522 WP_004144730.1 flavodoxin FldB -
AQD68_RS18090 3615976..3616872 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AQD68_RS18095 3616895..3617608 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AQD68_RS18100 3617614..3619347 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T57614 WP_002916310.1 NZ_CP012987:3614937-3615347 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T57614 NZ_CP012987:3614937-3615347 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGTTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT57614 WP_002916312.1 NZ_CP012987:3614690-3614956 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT57614 NZ_CP012987:3614690-3614956 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References