Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2229481..2229997 Replicon chromosome
Accession NZ_CP012987
Organism Klebsiella pneumoniae strain KpN01

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag AQD68_RS11055 Protein ID WP_004178374.1
Coordinates 2229481..2229765 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag AQD68_RS11060 Protein ID WP_004192397.1
Coordinates 2229755..2229997 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQD68_RS11025 2224877..2225185 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
AQD68_RS31530 2225270..2225443 + 174 WP_002886906.1 hypothetical protein -
AQD68_RS11035 2225446..2226189 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AQD68_RS11045 2226546..2228684 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AQD68_RS11050 2229013..2229477 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AQD68_RS11055 2229481..2229765 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQD68_RS11060 2229755..2229997 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AQD68_RS11065 2230075..2231985 - 1911 WP_004152270.1 BglG family transcription antiterminator -
AQD68_RS11070 2232008..2233162 - 1155 WP_004178372.1 lactonase family protein -
AQD68_RS11075 2233229..2233969 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T57609 WP_004178374.1 NZ_CP012987:c2229765-2229481 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T57609 NZ_CP012987:c2229765-2229481 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT57609 WP_004192397.1 NZ_CP012987:c2229997-2229755 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT57609 NZ_CP012987:c2229997-2229755 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References