Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2732502..2734252 Replicon chromosome
Accession NZ_CP012982
Organism Burkholderia cepacia ATCC 25416 strain UCB 717

Toxin (Protein)


Gene name doc Uniprot ID A0A806V0L2
Locus tag APZ15_RS29485 Protein ID WP_027789380.1
Coordinates 2732502..2733398 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4S5DGT0
Locus tag APZ15_RS29490 Protein ID WP_027789379.1
Coordinates 2733395..2734252 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ15_RS29455 2727877..2728956 - 1080 WP_027789386.1 porin -
APZ15_RS29460 2729402..2729719 + 318 WP_027789384.1 non-heme iron oxygenase ferredoxin subunit -
APZ15_RS29465 2729723..2730034 + 312 WP_027789383.1 hypothetical protein -
APZ15_RS29470 2730089..2731159 + 1071 WP_027789382.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
APZ15_RS29475 2731152..2731922 + 771 WP_027789381.1 SDR family oxidoreductase -
APZ15_RS29480 2731956..2732483 + 528 WP_021161513.1 cupin domain-containing protein -
APZ15_RS29485 2732502..2733398 + 897 WP_027789380.1 alpha/beta fold hydrolase Toxin
APZ15_RS29490 2733395..2734252 + 858 WP_027789379.1 IclR family transcriptional regulator Antitoxin
APZ15_RS29495 2734249..2735046 + 798 WP_027789378.1 SDR family oxidoreductase -
APZ15_RS29500 2735039..2736706 + 1668 WP_027789377.1 thiamine pyrophosphate-binding protein -
APZ15_RS29505 2736699..2737526 + 828 WP_027789376.1 aspartate dehydrogenase -
APZ15_RS29510 2737599..2739089 + 1491 WP_027789375.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30635.82 Da        Isoelectric Point: 7.7327

>T57603 WP_027789380.1 NZ_CP012982:2732502-2733398 [Burkholderia cepacia ATCC 25416]
MSVIDKRERDRTATFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRQCDQQRGLA

Download         Length: 897 bp

>T57603 NZ_CP012982:2732502-2733398 [Burkholderia cepacia ATCC 25416]
ATGAGTGTCATCGACAAACGTGAGCGCGACCGCACCGCGACGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCAGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCCTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GAATCGCGCCGCGACGCACGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGTTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGTCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGGCATGCCGGTTATGTCGAGGCTCCGGCCGTCTATTCCGCACTGATCGACTCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31511.04 Da        Isoelectric Point: 6.5068

>AT57603 WP_027789379.1 NZ_CP012982:2733395-2734252 [Burkholderia cepacia ATCC 25416]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT57603 NZ_CP012982:2733395-2734252 [Burkholderia cepacia ATCC 25416]
ATGAACGAACCGCTGCAACGACCCGAACCCGAAAACGACAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGCCTGCTGCAGACGCTCGAGTCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTTGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACACACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTCTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCACTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGCGGCGCTGATCGCCGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTATGAAAGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806V0L2

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5DGT0

References