Detailed information of TA system TA057602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2600996..2601651
• Replicon: chromosome
• Accession: NZ_CP012982
• Organism: Burkholderia cepacia ATCC 25416 strain UCB 717

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2HGC0
• Locus tag: APZ15_RS40000
• Protein ID: WP_021158162.1
• Coordinates: 2601232..2601651 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2HMP5
• Locus tag: APZ15_RS28840
• Protein ID: WP_021158161.1
• Coordinates: 2600996..2601235 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APZ15_RS28815	2596281..2596676	-	396	WP_027789497.1	type II toxin-antitoxin system VapC family toxin	-
APZ15_RS28820	2596673..2596912	-	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
APZ15_RS28825	2597001..2597684	-	684	WP_027789496.1	Fe2+-dependent dioxygenase	-
APZ15_RS28830	2597681..2598436	-	756	WP_027789495.1	sel1 repeat family protein	-
APZ15_RS28835	2598440..2600686	-	2247	WP_027789494.1	TonB-dependent siderophore receptor	-
APZ15_RS28840	2600996..2601235	+	240	WP_021158161.1	antitoxin VapB	Antitoxin
APZ15_RS40000	2601232..2601651	+	420	WP_021158162.1	type II toxin-antitoxin system VapC family toxin	Toxin
APZ15_RS28850	2601787..2603082	-	1296	WP_027789492.1	aspartate carbamoyltransferase	-
APZ15_RS28855	2603316..2603450	+	135	WP_021158165.1	entericidin A/B family lipoprotein	-
APZ15_RS28860	2603554..2604102	-	549	WP_027789491.1	hypothetical protein	-
APZ15_RS28865	2604287..2605240	-	954	WP_027789490.1	DMT family transporter	-
APZ15_RS28870	2605500..2606294	-	795	WP_027789489.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15212.57 Da
• Isoelectric Point: 5.9052

>T57602 WP_021158162.1 NZ_CP012982:2601232-2601651 [Burkholderia cepacia ATCC 25416]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T57602 NZ_CP012982:2601232-2601651 [Burkholderia cepacia ATCC 25416]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGACGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGATCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCATTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACGCGCTCGTGCCGCAGGTGTCGCAATTGCACCATCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGATGTCACGCCGTTCGAGGCAATGGGAATTCGCGTAA
TCGACCCGTGGGCGCGCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8629.79 Da
• Isoelectric Point: 5.6643

>AT57602 WP_021158161.1 NZ_CP012982:2600996-2601235 [Burkholderia cepacia ATCC 25416]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT57602 NZ_CP012982:2600996-2601235 [Burkholderia cepacia ATCC 25416]
ATGCCGGTGATCACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCAGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGATCCGATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: U2HGC0

Antitoxin

• AlphaFold DB: U2HMP5