Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2448991..2450212 | Replicon | chromosome |
| Accession | NZ_CP012982 | ||
| Organism | Burkholderia cepacia ATCC 25416 strain UCB 717 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A806V019 |
| Locus tag | APZ15_RS28195 | Protein ID | WP_027789605.1 |
| Coordinates | 2448991..2449572 (-) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A806V242 |
| Locus tag | APZ15_RS28200 | Protein ID | WP_027789604.1 |
| Coordinates | 2449655..2450212 (-) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| APZ15_RS28180 | 2444666..2446726 | - | 2061 | WP_027789608.1 | MacB family efflux pump subunit | - |
| APZ15_RS28185 | 2446729..2447922 | - | 1194 | WP_027789607.1 | macrolide transporter subunit MacA | - |
| APZ15_RS28190 | 2448207..2448935 | - | 729 | WP_027789606.1 | class I SAM-dependent methyltransferase | - |
| APZ15_RS28195 | 2448991..2449572 | - | 582 | WP_027789605.1 | HD domain-containing protein | Toxin |
| APZ15_RS28200 | 2449655..2450212 | - | 558 | WP_027789604.1 | helix-turn-helix domain-containing protein | Antitoxin |
| APZ15_RS28205 | 2450267..2450944 | - | 678 | WP_027789603.1 | hypothetical protein | - |
| APZ15_RS28210 | 2451305..2452708 | + | 1404 | WP_027789602.1 | membrane protein | - |
| APZ15_RS28215 | 2452805..2453383 | + | 579 | WP_027789601.1 | hypothetical protein | - |
| APZ15_RS28220 | 2453465..2453854 | - | 390 | WP_027789600.1 | OsmC family protein | - |
| APZ15_RS28225 | 2454085..2454816 | + | 732 | WP_027789599.1 | ribonuclease T2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21301.86 Da Isoelectric Point: 4.9552
>T57601 WP_027789605.1 NZ_CP012982:c2449572-2448991 [Burkholderia cepacia ATCC 25416]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPARRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQHE
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPARRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQHE
Download Length: 582 bp
>T57601 NZ_CP012982:c2449572-2448991 [Burkholderia cepacia ATCC 25416]
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGTGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCACGGCGCGACGAAATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCAGCAACCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGGGTGGGCAGCACGAGTAA
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGTGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCACGGCGCGACGAAATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCAGCAACCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGGGTGGGCAGCACGAGTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 19990.98 Da Isoelectric Point: 10.2051
>AT57601 WP_027789604.1 NZ_CP012982:c2450212-2449655 [Burkholderia cepacia ATCC 25416]
MSASPLHAPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERAAAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGAAARLVETL
MSASPLHAPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERAAAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGAAARLVETL
Download Length: 558 bp
>AT57601 NZ_CP012982:c2450212-2449655 [Burkholderia cepacia ATCC 25416]
ATGTCTGCCTCACCGCTACACGCACCACCACTCGGCCCGCAACTCAAGCGCTGGCGAGCGCTGCACCGCGTGAAGCAGAG
CCACGCGGCGGAGCTGTTCGGCGTGGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGGCGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGGCTACTTGCCTGTTCGCCCGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGGCGGCCGCGCGGCTCGTGGAAACGCTGTAA
ATGTCTGCCTCACCGCTACACGCACCACCACTCGGCCCGCAACTCAAGCGCTGGCGAGCGCTGCACCGCGTGAAGCAGAG
CCACGCGGCGGAGCTGTTCGGCGTGGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGGCGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGGCTACTTGCCTGTTCGCCCGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGGCGGCCGCGCGGCTCGTGGAAACGCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A806V019 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A806V242 |