Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 67836..68875 | Replicon | chromosome |
| Accession | NZ_CP012982 | ||
| Organism | Burkholderia cepacia ATCC 25416 strain UCB 717 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A806V135 |
| Locus tag | APZ15_RS17795 | Protein ID | WP_027791437.1 |
| Coordinates | 67836..68411 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A806V2D4 |
| Locus tag | APZ15_RS17800 | Protein ID | WP_027791436.1 |
| Coordinates | 68408..68875 (-) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| APZ15_RS17770 | 63153..64220 | + | 1068 | WP_027791442.1 | ABC transporter ATP-binding protein | - |
| APZ15_RS17775 | 64380..65471 | + | 1092 | WP_034196044.1 | porin | - |
| APZ15_RS17780 | 65642..66607 | - | 966 | WP_027791440.1 | zinc-binding alcohol dehydrogenase family protein | - |
| APZ15_RS17785 | 66654..66905 | - | 252 | WP_027791439.1 | hypothetical protein | - |
| APZ15_RS17790 | 67001..67780 | + | 780 | WP_027791438.1 | helix-turn-helix transcriptional regulator | - |
| APZ15_RS17795 | 67836..68411 | - | 576 | WP_027791437.1 | PIN domain-containing protein | Toxin |
| APZ15_RS17800 | 68408..68875 | - | 468 | WP_027791436.1 | helix-turn-helix domain-containing protein | Antitoxin |
| APZ15_RS17805 | 68985..69791 | - | 807 | WP_027791435.1 | 4-hydroxy-2-oxoheptanedioate aldolase | - |
| APZ15_RS17810 | 69804..70607 | - | 804 | WP_021164056.1 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | - |
| APZ15_RS17815 | 70628..71020 | - | 393 | WP_027791434.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | - |
| APZ15_RS17820 | 71054..71902 | - | 849 | WP_027791433.1 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | - |
| APZ15_RS17825 | 71952..73415 | - | 1464 | WP_027791432.1 | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21502.82 Da Isoelectric Point: 5.6556
>T57596 WP_027791437.1 NZ_CP012982:c68411-67836 [Burkholderia cepacia ATCC 25416]
MTSSPFTAVYDACVLYPAPLRDFLMWLALSGCFRARWSVDIHDEWKRNLLRNRADLTAAQLDRTASLMDRAIPDALVTGY
EALIGGLTLPDANDRHVLAAAIRCNASVIVTFNQKDFPEEVLSIYGVEAQHPDVFVDNLFDLEPAAVVAAARRQRETLKH
PPMIVERYLEILQRLGMVQTCKALEAYRTII
MTSSPFTAVYDACVLYPAPLRDFLMWLALSGCFRARWSVDIHDEWKRNLLRNRADLTAAQLDRTASLMDRAIPDALVTGY
EALIGGLTLPDANDRHVLAAAIRCNASVIVTFNQKDFPEEVLSIYGVEAQHPDVFVDNLFDLEPAAVVAAARRQRETLKH
PPMIVERYLEILQRLGMVQTCKALEAYRTII
Download Length: 576 bp
>T57596 NZ_CP012982:c68411-67836 [Burkholderia cepacia ATCC 25416]
ATGACGAGTTCGCCATTCACGGCGGTCTACGATGCGTGCGTGCTTTATCCCGCACCGCTGCGTGATTTCCTGATGTGGCT
GGCGCTGAGCGGATGTTTTCGGGCTCGCTGGAGTGTGGATATTCATGACGAATGGAAACGGAATCTGCTGCGTAACCGGG
CCGATCTGACCGCGGCGCAACTCGATCGCACGGCAAGCCTGATGGATAGGGCGATACCCGATGCGCTCGTTACCGGTTAC
GAGGCGCTGATTGGTGGGCTGACGCTGCCGGACGCGAACGATCGACATGTGCTCGCTGCCGCGATCCGCTGCAACGCCAG
CGTGATCGTTACGTTCAATCAGAAGGATTTCCCCGAAGAAGTGTTGTCGATCTACGGTGTCGAAGCACAGCACCCTGACG
TGTTCGTCGACAATCTCTTCGATCTCGAACCGGCCGCAGTGGTCGCCGCCGCTCGGCGGCAGCGCGAAACACTCAAGCAT
CCACCGATGATTGTGGAGCGCTATCTGGAAATCTTGCAGCGTCTGGGGATGGTTCAGACCTGCAAGGCACTCGAAGCCTA
TCGGACGATTATTTGA
ATGACGAGTTCGCCATTCACGGCGGTCTACGATGCGTGCGTGCTTTATCCCGCACCGCTGCGTGATTTCCTGATGTGGCT
GGCGCTGAGCGGATGTTTTCGGGCTCGCTGGAGTGTGGATATTCATGACGAATGGAAACGGAATCTGCTGCGTAACCGGG
CCGATCTGACCGCGGCGCAACTCGATCGCACGGCAAGCCTGATGGATAGGGCGATACCCGATGCGCTCGTTACCGGTTAC
GAGGCGCTGATTGGTGGGCTGACGCTGCCGGACGCGAACGATCGACATGTGCTCGCTGCCGCGATCCGCTGCAACGCCAG
CGTGATCGTTACGTTCAATCAGAAGGATTTCCCCGAAGAAGTGTTGTCGATCTACGGTGTCGAAGCACAGCACCCTGACG
TGTTCGTCGACAATCTCTTCGATCTCGAACCGGCCGCAGTGGTCGCCGCCGCTCGGCGGCAGCGCGAAACACTCAAGCAT
CCACCGATGATTGTGGAGCGCTATCTGGAAATCTTGCAGCGTCTGGGGATGGTTCAGACCTGCAAGGCACTCGAAGCCTA
TCGGACGATTATTTGA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17497.87 Da Isoelectric Point: 6.2956
>AT57596 WP_027791436.1 NZ_CP012982:c68875-68408 [Burkholderia cepacia ATCC 25416]
MPHTTMSETILPVEREMRAAVEGQRALAAYLATRTEIQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPHHKTGKHRRVRFSDLMRYKAERDQASADAMEELSRQAQEHGMGYE
MPHTTMSETILPVEREMRAAVEGQRALAAYLATRTEIQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPHHKTGKHRRVRFSDLMRYKAERDQASADAMEELSRQAQEHGMGYE
Download Length: 468 bp
>AT57596 NZ_CP012982:c68875-68408 [Burkholderia cepacia ATCC 25416]
ATGCCTCACACCACGATGTCCGAAACGATCTTGCCTGTCGAGCGCGAGATGCGGGCGGCTGTCGAAGGGCAGCGTGCGCT
TGCGGCATACCTGGCAACGCGAACGGAAATACAGCGCATCCAGATCTTCGACGACGAAAATCGCGCGCATCAGGTCGAAC
TTCCGACCTCCGCGCTGCGTCTGCTGGTCGATATCCTCGCCGAGTTGGCCGACGGCAATGCGGTCAAGGTCGTGCCGGTT
CATGCGGAACTGACGACACAGGAAGCGGCCGACCTGTTGAACGTTTCTCGTCCGCACCTGATCAAGCTGCTCGAATCGAA
TGCGCTTCCGCACCACAAGACCGGCAAGCATCGCCGTGTGCGATTTTCCGACCTGATGCGTTACAAGGCGGAACGCGATC
AGGCAAGCGCGGACGCGATGGAGGAGTTGAGCCGGCAGGCGCAAGAGCACGGGATGGGGTACGAATGA
ATGCCTCACACCACGATGTCCGAAACGATCTTGCCTGTCGAGCGCGAGATGCGGGCGGCTGTCGAAGGGCAGCGTGCGCT
TGCGGCATACCTGGCAACGCGAACGGAAATACAGCGCATCCAGATCTTCGACGACGAAAATCGCGCGCATCAGGTCGAAC
TTCCGACCTCCGCGCTGCGTCTGCTGGTCGATATCCTCGCCGAGTTGGCCGACGGCAATGCGGTCAAGGTCGTGCCGGTT
CATGCGGAACTGACGACACAGGAAGCGGCCGACCTGTTGAACGTTTCTCGTCCGCACCTGATCAAGCTGCTCGAATCGAA
TGCGCTTCCGCACCACAAGACCGGCAAGCATCGCCGTGTGCGATTTTCCGACCTGATGCGTTACAAGGCGGAACGCGATC
AGGCAAGCGCGGACGCGATGGAGGAGTTGAGCCGGCAGGCGCAAGAGCACGGGATGGGGTACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A806V135 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A806V2D4 |