Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2777785..2778458 Replicon chromosome
Accession NZ_CP012981
Organism Burkholderia cepacia ATCC 25416 strain UCB 717

Toxin (Protein)


Gene name vagD Uniprot ID A0A0J5X1U9
Locus tag APZ15_RS12810 Protein ID WP_027787436.1
Coordinates 2778042..2778458 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A4S5D574
Locus tag APZ15_RS12805 Protein ID WP_049096496.1
Coordinates 2777785..2778045 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ15_RS12790 2773340..2775592 + 2253 WP_027787439.1 TonB-dependent siderophore receptor -
APZ15_RS12795 2775679..2776518 + 840 WP_027787438.1 N(5)-hydroxyornithine transformylase PvdF -
APZ15_RS12800 2776518..2777534 + 1017 WP_027787437.1 acetyltransferase -
APZ15_RS12805 2777785..2778045 + 261 WP_049096496.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
APZ15_RS12810 2778042..2778458 + 417 WP_027787436.1 PIN domain-containing protein Toxin
APZ15_RS12815 2778513..2779418 - 906 WP_027787435.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
APZ15_RS12820 2779387..2780460 - 1074 WP_027787434.1 hypothetical protein -
APZ15_RS12825 2780802..2781965 + 1164 WP_027787433.1 amidohydrolase -
APZ15_RS12830 2782119..2782658 + 540 WP_027787432.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14536.66 Da        Isoelectric Point: 7.8895

>T57595 WP_027787436.1 NZ_CP012981:2778042-2778458 [Burkholderia cepacia ATCC 25416]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T57595 NZ_CP012981:2778042-2778458 [Burkholderia cepacia ATCC 25416]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCGACGGCCGCGATTCGTGCCGATCTCGCCGCGCGCGGCACGCCGATCGGTGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCCGCCGGTGCGGTGCTCGTCACGAACAACGGCCGGGAATTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9564.84 Da        Isoelectric Point: 4.6151

>AT57595 WP_049096496.1 NZ_CP012981:2777785-2778045 [Burkholderia cepacia ATCC 25416]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLMLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp

>AT57595 NZ_CP012981:2777785-2778045 [Burkholderia cepacia ATCC 25416]
ATGCGTACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACACTGATGCTGCGGCCGGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5X1U9

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5D574

References