Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1030710..1031347 Replicon chromosome
Accession NZ_CP012981
Organism Burkholderia cepacia ATCC 25416 strain UCB 717

Toxin (Protein)


Gene name vapC Uniprot ID A0A806UUZ0
Locus tag APZ15_RS04645 Protein ID WP_027788677.1
Coordinates 1030946..1031347 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1Z3YWA1
Locus tag APZ15_RS04640 Protein ID WP_027788678.1
Coordinates 1030710..1030946 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ15_RS04620 1026688..1027830 - 1143 WP_049097352.1 ADP-heptose--LPS heptosyltransferase -
APZ15_RS04625 1027827..1029530 - 1704 WP_027788681.1 thiamine pyrophosphate-binding protein -
APZ15_RS04630 1029831..1030292 + 462 WP_027788680.1 hypothetical protein -
APZ15_RS04635 1030289..1030573 + 285 WP_027788679.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
APZ15_RS04640 1030710..1030946 + 237 WP_027788678.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
APZ15_RS04645 1030946..1031347 + 402 WP_027788677.1 type II toxin-antitoxin system VapC family toxin Toxin
APZ15_RS04650 1031414..1032802 - 1389 WP_027788676.1 L-serine ammonia-lyase -
APZ15_RS04655 1032833..1033969 - 1137 WP_027788675.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14959.06 Da        Isoelectric Point: 5.1684

>T57594 WP_027788677.1 NZ_CP012981:1030946-1031347 [Burkholderia cepacia ATCC 25416]
MPRYMLDTNMCIYLMKNQPEQVAKQFAQCYTGDVVMSAITYAELEYGVAACANPARERRHLAALIDDIPVAPFDVAAAQA
YGPVRDATRERKRDHLDKLIAAHAVSLDVALVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T57594 NZ_CP012981:1030946-1031347 [Burkholderia cepacia ATCC 25416]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCCGAGCAAGTCGCGAAACAATTTGC
GCAGTGCTACACGGGGGATGTGGTGATGTCGGCGATCACGTATGCCGAGCTCGAGTACGGCGTCGCCGCATGTGCGAATC
CTGCGCGGGAGCGTCGCCATCTCGCCGCGCTGATCGACGATATCCCCGTTGCTCCGTTCGACGTCGCGGCGGCGCAAGCG
TACGGTCCGGTCCGCGACGCAACCCGCGAGCGGAAGAGGGATCATCTCGACAAGCTGATCGCCGCGCACGCGGTGTCGCT
CGACGTTGCGCTCGTGACCAACAACGAGCGGGATTTCGTCAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9144.34 Da        Isoelectric Point: 5.1974

>AT57594 WP_027788678.1 NZ_CP012981:1030710-1030946 [Burkholderia cepacia ATCC 25416]
MHTTKVFRNGNSQAVRIPADLAYERNDIELEIERIGDEIRIRPMRRPLTRVLEKFAKFGPDFMAEGRGDQEQADREEL

Download         Length: 237 bp

>AT57594 NZ_CP012981:1030710-1030946 [Burkholderia cepacia ATCC 25416]
ATGCACACGACGAAGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTCGCCTATGAGCGTAACGA
TATCGAACTGGAAATCGAGCGTATCGGTGACGAAATCCGTATTCGACCGATGCGGCGGCCGTTGACCCGCGTACTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAAGGGCGCGGCGACCAGGAGCAGGCCGATCGCGAGGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806UUZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3YWA1

References