Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 823113..823590 Replicon chromosome
Accession NZ_CP012976
Organism Staphylococcus aureus strain ST20130942

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAST42_RS03990 Protein ID WP_000052076.1
Coordinates 823113..823301 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAST42_RS03995 Protein ID WP_001059690.1
Coordinates 823330..823590 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST42_RS03960 819104..819625 + 522 WP_000824484.1 hypothetical protein -
SAST42_RS03965 819966..820652 + 687 WP_000141557.1 thermonuclease family protein -
SAST42_RS03970 821009..821209 + 201 WP_001059082.1 cold-shock protein -
SAST42_RS03975 821704..821922 - 219 WP_000005884.1 hypothetical protein -
SAST42_RS03980 821984..822268 - 285 WP_001004399.1 hypothetical protein -
SAST42_RS03985 822356..822925 - 570 WP_001106655.1 hypothetical protein -
SAST42_RS03990 823113..823301 - 189 WP_000052076.1 hypothetical protein Toxin
SAST42_RS03995 823330..823590 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAST42_RS04000 823931..824134 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAST42_RS04005 824131..824367 - 237 WP_000368687.1 hypothetical protein -
SAST42_RS04010 824592..825173 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAST42_RS04015 825246..825863 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAST42_RS04020 826018..826512 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAST42_RS04025 826911..827333 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SAST42_RS04030 827481..828197 + 717 WP_000150018.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T57558 WP_000052076.1 NZ_CP012976:c823301-823113 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T57558 NZ_CP012976:c823301-823113 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT57558 WP_001059690.1 NZ_CP012976:c823590-823330 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT57558 NZ_CP012976:c823590-823330 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References