Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 823104..823581 Replicon chromosome
Accession NZ_CP012974
Organism Staphylococcus aureus strain ST20130943

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAST43_RS03990 Protein ID WP_000052076.1
Coordinates 823104..823292 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAST43_RS03995 Protein ID WP_001059690.1
Coordinates 823321..823581 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST43_RS03960 819095..819616 + 522 WP_000824484.1 hypothetical protein -
SAST43_RS03965 819957..820643 + 687 WP_000141557.1 thermonuclease family protein -
SAST43_RS03970 821000..821200 + 201 WP_001059082.1 cold-shock protein -
SAST43_RS03975 821695..821913 - 219 WP_000005884.1 hypothetical protein -
SAST43_RS03980 821975..822259 - 285 WP_001004399.1 hypothetical protein -
SAST43_RS03985 822347..822916 - 570 WP_001106655.1 hypothetical protein -
SAST43_RS03990 823104..823292 - 189 WP_000052076.1 hypothetical protein Toxin
SAST43_RS03995 823321..823581 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAST43_RS04000 823922..824125 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAST43_RS04005 824122..824358 - 237 WP_000368687.1 hypothetical protein -
SAST43_RS04010 824583..825164 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAST43_RS04015 825237..825854 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SAST43_RS04020 826009..826503 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAST43_RS04025 826901..827323 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SAST43_RS04030 827471..828187 + 717 WP_000150018.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(5-46)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T57543 WP_000052076.1 NZ_CP012974:c823292-823104 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T57543 NZ_CP012974:c823292-823104 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT57543 WP_001059690.1 NZ_CP012974:c823581-823321 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT57543 NZ_CP012974:c823581-823321 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References