57533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1063069..1063860 Replicon chromosome
Accession NZ_CP012972
Organism Staphylococcus aureus strain ST20130938

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag SAST38_RS05200 Protein ID WP_000525007.1
Coordinates 1063069..1063533 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SAST38_RS05205 Protein ID WP_000333630.1
Coordinates 1063546..1063860 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST38_RS05165 1058259..1059398 - 1140 WP_000843616.1 nucleotidyltransferase -
SAST38_RS05170 1059525..1060082 + 558 WP_000872155.1 DUF177 domain-containing protein -
SAST38_RS05180 1060162..1060335 + 174 WP_000290472.1 50S ribosomal protein L32 -
SAST38_RS05185 1060452..1061837 - 1386 WP_000861313.1 recombinase family protein -
SAST38_RS05190 1061946..1062125 + 180 WP_000337827.1 hypothetical protein -
SAST38_RS05195 1062105..1063037 - 933 WP_000392183.1 hypothetical protein -
SAST38_RS05200 1063069..1063533 - 465 WP_000525007.1 hypothetical protein Toxin
SAST38_RS05205 1063546..1063860 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
SAST38_RS05210 1064012..1064248 + 237 WP_001121116.1 helix-turn-helix domain-containing protein -
SAST38_RS05215 1064262..1064441 + 180 WP_000438352.1 hypothetical protein -
SAST38_RS05220 1064542..1065024 - 483 WP_000394410.1 hypothetical protein -
SAST38_RS05225 1065084..1065875 + 792 WP_001148563.1 phage antirepressor KilAC domain-containing protein -
SAST38_RS05230 1065876..1066100 + 225 WP_000187184.1 hypothetical protein -
SAST38_RS14645 1066140..1066316 + 177 WP_190362524.1 hypothetical protein -
SAST38_RS05235 1066291..1066521 - 231 WP_000395457.1 hypothetical protein -
SAST38_RS05240 1066701..1066862 + 162 WP_000066011.1 DUF1270 domain-containing protein -
SAST38_RS05245 1066959..1067219 + 261 WP_000291089.1 DUF1108 family protein -
SAST38_RS05250 1067229..1067450 + 222 WP_000815402.1 DUF2483 family protein -
SAST38_RS05255 1067443..1068066 + 624 WP_000139720.1 DUF1071 domain-containing protein -
SAST38_RS05260 1068066..1068494 + 429 WP_000934385.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1055290..1103528 48238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T57533 WP_000525007.1 NZ_CP012972:c1063533-1063069 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T57533 NZ_CP012972:c1063533-1063069 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT57533 WP_000333630.1 NZ_CP012972:c1063860-1063546 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT57533 NZ_CP012972:c1063860-1063546 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATTTA
GAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References