Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 814870..815347 | Replicon | chromosome |
Accession | NZ_CP012972 | ||
Organism | Staphylococcus aureus strain ST20130938 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | SAST38_RS03930 | Protein ID | WP_000052076.1 |
Coordinates | 814870..815058 (-) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | SAST38_RS03935 | Protein ID | WP_001059690.1 |
Coordinates | 815087..815347 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SAST38_RS03900 | 810911..811381 | + | 471 | WP_000824467.1 | hypothetical protein | - |
SAST38_RS03905 | 811722..812408 | + | 687 | WP_001641381.1 | thermonuclease family protein | - |
SAST38_RS03910 | 812765..812965 | + | 201 | WP_001059082.1 | cold-shock protein | - |
SAST38_RS03915 | 813461..813679 | - | 219 | WP_000005886.1 | hypothetical protein | - |
SAST38_RS03920 | 813741..814025 | - | 285 | WP_001004401.1 | hypothetical protein | - |
SAST38_RS03925 | 814113..814682 | - | 570 | WP_001106654.1 | hypothetical protein | - |
SAST38_RS03930 | 814870..815058 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
SAST38_RS03935 | 815087..815347 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
SAST38_RS03940 | 815688..815891 | + | 204 | WP_000145164.1 | sterile alpha motif-like domain-containing protein | - |
SAST38_RS03945 | 815888..816124 | - | 237 | WP_000368687.1 | hypothetical protein | - |
SAST38_RS03950 | 816349..816930 | + | 582 | WP_001140693.1 | phosphoglycerate mutase family protein | - |
SAST38_RS03955 | 817003..817620 | - | 618 | WP_000255557.1 | LysE/ArgO family amino acid transporter | - |
SAST38_RS03960 | 817708..819354 | - | 1647 | WP_000277718.1 | IS1182 family transposase | - |
SAST38_RS03965 | 819693..820187 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 817708..819354 | 1646 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T57532 WP_000052076.1 NZ_CP012972:c815058-814870 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T57532 NZ_CP012972:c815058-814870 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT57532 WP_001059690.1 NZ_CP012972:c815347-815087 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT57532 NZ_CP012972:c815347-815087 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |