Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1063458..1064249 Replicon chromosome
Accession NZ_CP012970
Organism Staphylococcus aureus strain ST20130939

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag SAST39_RS05200 Protein ID WP_000525007.1
Coordinates 1063458..1063922 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SAST39_RS05205 Protein ID WP_000333630.1
Coordinates 1063935..1064249 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST39_RS05165 1058648..1059787 - 1140 WP_000843616.1 nucleotidyltransferase -
SAST39_RS05170 1059914..1060471 + 558 WP_000872155.1 DUF177 domain-containing protein -
SAST39_RS05180 1060551..1060724 + 174 WP_000290472.1 50S ribosomal protein L32 -
SAST39_RS05185 1060841..1062226 - 1386 WP_000861313.1 recombinase family protein -
SAST39_RS05190 1062335..1062514 + 180 WP_000337827.1 hypothetical protein -
SAST39_RS05195 1062494..1063426 - 933 WP_000392183.1 hypothetical protein -
SAST39_RS05200 1063458..1063922 - 465 WP_000525007.1 hypothetical protein Toxin
SAST39_RS05205 1063935..1064249 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
SAST39_RS05210 1064401..1064637 + 237 WP_001121116.1 helix-turn-helix domain-containing protein -
SAST39_RS05215 1064651..1064830 + 180 WP_000438352.1 hypothetical protein -
SAST39_RS05220 1064931..1065413 - 483 WP_000394410.1 hypothetical protein -
SAST39_RS05225 1065473..1066264 + 792 WP_001148563.1 phage antirepressor KilAC domain-containing protein -
SAST39_RS05230 1066265..1066489 + 225 WP_000187184.1 hypothetical protein -
SAST39_RS14620 1066529..1066705 + 177 WP_190362524.1 hypothetical protein -
SAST39_RS05235 1066680..1066910 - 231 WP_000395457.1 hypothetical protein -
SAST39_RS05240 1067090..1067251 + 162 WP_000066011.1 DUF1270 domain-containing protein -
SAST39_RS05245 1067348..1067608 + 261 WP_000291089.1 DUF1108 family protein -
SAST39_RS05250 1067618..1067839 + 222 WP_000815402.1 DUF2483 family protein -
SAST39_RS05255 1067832..1068455 + 624 WP_000139720.1 DUF1071 domain-containing protein -
SAST39_RS05260 1068455..1068883 + 429 WP_000934385.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1055679..1103918 48239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T57522 WP_000525007.1 NZ_CP012970:c1063922-1063458 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T57522 NZ_CP012970:c1063922-1063458 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCGCACAATTACGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGTACTC
ACTACGGCGAATTCTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT57522 WP_000333630.1 NZ_CP012970:c1064249-1063935 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT57522 NZ_CP012970:c1064249-1063935 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATTTA
GAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References