Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 815180..815657 Replicon chromosome
Accession NZ_CP012970
Organism Staphylococcus aureus strain ST20130939

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAST39_RS03925 Protein ID WP_000052076.1
Coordinates 815180..815368 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAST39_RS03930 Protein ID WP_001059690.1
Coordinates 815397..815657 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST39_RS03895 811221..811691 + 471 WP_000824467.1 hypothetical protein -
SAST39_RS03900 812032..812718 + 687 WP_001641381.1 thermonuclease family protein -
SAST39_RS03905 813075..813275 + 201 WP_001059082.1 cold-shock protein -
SAST39_RS03910 813771..813989 - 219 WP_000005886.1 hypothetical protein -
SAST39_RS03915 814051..814335 - 285 WP_001004401.1 hypothetical protein -
SAST39_RS03920 814423..814992 - 570 WP_001106654.1 hypothetical protein -
SAST39_RS03925 815180..815368 - 189 WP_000052076.1 hypothetical protein Toxin
SAST39_RS03930 815397..815657 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAST39_RS03935 815998..816201 + 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
SAST39_RS03940 816198..816434 - 237 WP_000368687.1 hypothetical protein -
SAST39_RS03945 816659..817240 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAST39_RS03950 817313..817930 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
SAST39_RS03955 818018..819664 - 1647 WP_000277718.1 IS1182 family transposase -
SAST39_RS03960 820004..820498 - 495 WP_000569884.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 818018..819664 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T57521 WP_000052076.1 NZ_CP012970:c815368-815180 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T57521 NZ_CP012970:c815368-815180 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT57521 WP_001059690.1 NZ_CP012970:c815657-815397 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT57521 NZ_CP012970:c815657-815397 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References