Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2697054..2697703 Replicon chromosome
Accession NZ_CP012969
Organism Psychrobacter sp. AntiMn-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1D9D1X1
Locus tag AOT82_RS11580 Protein ID WP_071003130.1
Coordinates 2697404..2697703 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1D9D1W8
Locus tag AOT82_RS11575 Protein ID WP_071003129.1
Coordinates 2697054..2697401 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOT82_RS11535 2692235..2692687 - 453 WP_025645976.1 threonine/serine exporter family protein -
AOT82_RS11540 2692688..2693476 - 789 WP_025645975.1 threonine/serine exporter family protein -
AOT82_RS11545 2693594..2693875 + 282 WP_071003121.1 DUF503 domain-containing protein -
AOT82_RS11550 2693964..2694404 + 441 WP_071003125.1 hypothetical protein -
AOT82_RS11555 2694703..2695491 - 789 WP_071003126.1 hypothetical protein -
AOT82_RS11560 2695488..2695928 - 441 Protein_2257 transposase -
AOT82_RS11565 2695880..2696320 - 441 WP_071002207.1 IS5/IS1182 family transposase -
AOT82_RS11570 2696326..2696946 - 621 WP_071003128.1 hypothetical protein -
AOT82_RS11575 2697054..2697401 - 348 WP_071003129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AOT82_RS11580 2697404..2697703 - 300 WP_071003130.1 type II toxin-antitoxin system HicA family toxin Toxin
AOT82_RS11585 2697763..2699004 - 1242 WP_071003131.1 integrase arm-type DNA-binding domain-containing protein -
AOT82_RS11595 2699359..2700885 - 1527 WP_071003132.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
AOT82_RS11600 2700885..2702381 - 1497 WP_071003134.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10963.47 Da        Isoelectric Point: 6.7255

>T57520 WP_071003130.1 NZ_CP012969:c2697703-2697404 [Psychrobacter sp. AntiMn-1]
MQRKHLKTLNIIFTKPISANIKWADIEALFIALGAEVNERAGSRIAVVLDGEVQVYHRPHPQPTTDKGAVASVRKWLDSL
GYSPIDEAKDTAPVTNNEE

Download         Length: 300 bp

>T57520 NZ_CP012969:c2697703-2697404 [Psychrobacter sp. AntiMn-1]
ATGCAGCGCAAGCACCTAAAAACACTTAATATCATCTTTACTAAGCCTATATCAGCAAATATAAAGTGGGCAGACATTGA
AGCCTTATTTATAGCATTAGGTGCAGAGGTCAACGAACGGGCAGGATCAAGAATAGCTGTAGTGTTAGATGGTGAGGTAC
AAGTTTATCACCGACCACACCCCCAACCGACAACAGATAAGGGCGCAGTCGCTAGCGTTCGTAAATGGCTAGATAGTTTA
GGGTATAGCCCTATTGATGAAGCCAAAGACACCGCCCCCGTAACTAATAATGAGGAATAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12730.30 Da        Isoelectric Point: 4.3422

>AT57520 WP_071003129.1 NZ_CP012969:c2697401-2697054 [Psychrobacter sp. AntiMn-1]
MQNIMMINDHKALIQYDPELGLFRGEFVGLNGGADFYGDSIADLENEGKQSLQTFLDVCQEQGIEPYKSFSGKFVTRVPS
ELHEQVTTIATSHGMSLNQWVTNTLANAIKTEGMA

Download         Length: 348 bp

>AT57520 NZ_CP012969:c2697401-2697054 [Psychrobacter sp. AntiMn-1]
ATGCAAAACATTATGATGATTAATGACCATAAAGCACTTATTCAATATGACCCTGAACTAGGGTTATTCCGTGGAGAATT
TGTAGGGCTAAATGGTGGGGCAGACTTTTATGGTGACAGCATTGCCGATTTAGAAAATGAGGGTAAGCAGTCATTGCAAA
CCTTTTTGGACGTTTGCCAAGAACAAGGCATTGAGCCTTACAAATCCTTTTCAGGTAAGTTTGTAACCCGTGTGCCAAGT
GAGCTACACGAGCAAGTAACAACTATTGCCACCAGCCACGGTATGAGCCTTAACCAATGGGTCACTAATACACTTGCCAA
TGCCATCAAAACCGAAGGCATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D9D1X1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D9D1W8

References